3pcr

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[[Image:3pcr.png|left|200px]]
 
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{{STRUCTURE_3pcr| PDB=3pcr | SCENE= }}
{{STRUCTURE_3pcr| PDB=3pcr | SCENE= }}
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===Structure of EspG-Arf6 complex===
===Structure of EspG-Arf6 complex===
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{{ABSTRACT_PUBMED_21170023}}
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==Function==
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[[http://www.uniprot.org/uniprot/ARF6_HUMAN ARF6_HUMAN]] GTP-binding protein involved in protein trafficking; regulates endocytic recycling and cytoskeleton remodeling. May modulate vesicle budding and uncoating within the Golgi apparatus. Functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in the regulation of dendritic spine development (By similarity). Contributes to the regulation of dendritic branching and filopodia extension.<ref>PMID:7589240</ref> <ref>PMID:14978216</ref> <ref>PMID:11266366</ref>
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(as it appears on PubMed at http://www.pubmed.gov), where 21170023 is the PubMed ID number.
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{{ABSTRACT_PUBMED_21170023}}
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==About this Structure==
==About this Structure==
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[[3pcr]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_o157:h7 Escherichia coli o157:h7] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PCR OCA].
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[[3pcr]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PCR OCA].
==Reference==
==Reference==
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<ref group="xtra">PMID:21170023</ref><references group="xtra"/>
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<ref group="xtra">PMID:021170023</ref><references group="xtra"/><references/>
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[[Category: Escherichia coli o157:h7]]
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[[Category: Escherichia coli]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Alto, N M.]]
[[Category: Alto, N M.]]
[[Category: Selyunin, A S.]]
[[Category: Selyunin, A S.]]
[[Category: Tomchick, D R.]]
[[Category: Tomchick, D R.]]
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[[Category: Adp-ribosylation factor 6]]
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[[Category: Arf]]
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[[Category: Bacterial effector]]
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[[Category: Protein transport]]
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[[Category: Small g protein]]
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[[Category: Small gtp-binding protein]]

Revision as of 08:35, 2 May 2013

Template:STRUCTURE 3pcr

Contents

Structure of EspG-Arf6 complex

Template:ABSTRACT PUBMED 21170023

Function

[ARF6_HUMAN] GTP-binding protein involved in protein trafficking; regulates endocytic recycling and cytoskeleton remodeling. May modulate vesicle budding and uncoating within the Golgi apparatus. Functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in the regulation of dendritic spine development (By similarity). Contributes to the regulation of dendritic branching and filopodia extension.[1] [2] [3]

About this Structure

3pcr is a 2 chain structure with sequence from Escherichia coli and Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Selyunin AS, Sutton SE, Weigele BA, Reddick LE, Orchard RC, Bresson SM, Tomchick DR, Alto NM. The assembly of a GTPase-kinase signalling complex by a bacterial catalytic scaffold. Nature. 2010 Dec 19. PMID:21170023 doi:10.1038/nature09593
  1. ↑ D'Souza-Schorey C, Stahl PD. Myristoylation is required for the intracellular localization and endocytic function of ARF6. Exp Cell Res. 1995 Nov;221(1):153-9. PMID:7589240 doi:http://dx.doi.org/10.1006/excr.1995.1362
  2. ↑ Gauthier-Campbell C, Bredt DS, Murphy TH, El-Husseini Ael-D. Regulation of dendritic branching and filopodia formation in hippocampal neurons by specific acylated protein motifs. Mol Biol Cell. 2004 May;15(5):2205-17. Epub 2004 Feb 20. PMID:14978216 doi:10.1091/mbc.E03-07-0493
  3. ↑ Pasqualato S, Menetrey J, Franco M, Cherfils J. The structural GDP/GTP cycle of human Arf6. EMBO Rep. 2001 Mar;2(3):234-8. PMID:11266366 doi:10.1093/embo-reports/kve043

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