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3pcr
From Proteopedia
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{{STRUCTURE_3pcr| PDB=3pcr | SCENE= }} | {{STRUCTURE_3pcr| PDB=3pcr | SCENE= }} | ||
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===Structure of EspG-Arf6 complex=== | ===Structure of EspG-Arf6 complex=== | ||
| + | {{ABSTRACT_PUBMED_21170023}} | ||
| - | + | ==Function== | |
| - | + | [[http://www.uniprot.org/uniprot/ARF6_HUMAN ARF6_HUMAN]] GTP-binding protein involved in protein trafficking; regulates endocytic recycling and cytoskeleton remodeling. May modulate vesicle budding and uncoating within the Golgi apparatus. Functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in the regulation of dendritic spine development (By similarity). Contributes to the regulation of dendritic branching and filopodia extension.<ref>PMID:7589240</ref> <ref>PMID:14978216</ref> <ref>PMID:11266366</ref> | |
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==About this Structure== | ==About this Structure== | ||
| - | [[3pcr]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/ | + | [[3pcr]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PCR OCA]. |
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID: | + | <ref group="xtra">PMID:021170023</ref><references group="xtra"/><references/> |
| - | [[Category: Escherichia coli | + | [[Category: Escherichia coli]] |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Alto, N M.]] | [[Category: Alto, N M.]] | ||
[[Category: Selyunin, A S.]] | [[Category: Selyunin, A S.]] | ||
[[Category: Tomchick, D R.]] | [[Category: Tomchick, D R.]] | ||
| + | [[Category: Adp-ribosylation factor 6]] | ||
| + | [[Category: Arf]] | ||
| + | [[Category: Bacterial effector]] | ||
| + | [[Category: Protein transport]] | ||
| + | [[Category: Small g protein]] | ||
| + | [[Category: Small gtp-binding protein]] | ||
Revision as of 08:35, 2 May 2013
Contents |
Structure of EspG-Arf6 complex
Template:ABSTRACT PUBMED 21170023
Function
[ARF6_HUMAN] GTP-binding protein involved in protein trafficking; regulates endocytic recycling and cytoskeleton remodeling. May modulate vesicle budding and uncoating within the Golgi apparatus. Functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in the regulation of dendritic spine development (By similarity). Contributes to the regulation of dendritic branching and filopodia extension.[1] [2] [3]
About this Structure
3pcr is a 2 chain structure with sequence from Escherichia coli and Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Selyunin AS, Sutton SE, Weigele BA, Reddick LE, Orchard RC, Bresson SM, Tomchick DR, Alto NM. The assembly of a GTPase-kinase signalling complex by a bacterial catalytic scaffold. Nature. 2010 Dec 19. PMID:21170023 doi:10.1038/nature09593
- ↑ D'Souza-Schorey C, Stahl PD. Myristoylation is required for the intracellular localization and endocytic function of ARF6. Exp Cell Res. 1995 Nov;221(1):153-9. PMID:7589240 doi:http://dx.doi.org/10.1006/excr.1995.1362
- ↑ Gauthier-Campbell C, Bredt DS, Murphy TH, El-Husseini Ael-D. Regulation of dendritic branching and filopodia formation in hippocampal neurons by specific acylated protein motifs. Mol Biol Cell. 2004 May;15(5):2205-17. Epub 2004 Feb 20. PMID:14978216 doi:10.1091/mbc.E03-07-0493
- ↑ Pasqualato S, Menetrey J, Franco M, Cherfils J. The structural GDP/GTP cycle of human Arf6. EMBO Rep. 2001 Mar;2(3):234-8. PMID:11266366 doi:10.1093/embo-reports/kve043
