3ovs

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[[Image:3ovs.jpg|left|200px]]
 
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{{STRUCTURE_3ovs| PDB=3ovs | SCENE= }}
{{STRUCTURE_3ovs| PDB=3ovs | SCENE= }}
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===How the CCA-adding Enzyme Selects Adenine over Cytosine in Position 76 of tRNA===
===How the CCA-adding Enzyme Selects Adenine over Cytosine in Position 76 of tRNA===
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{{ABSTRACT_PUBMED_21071662}}
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==Function==
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[[http://www.uniprot.org/uniprot/CCA_ARCFU CCA_ARCFU]] Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate.<ref>PMID:14592988</ref>
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{{ABSTRACT_PUBMED_21071662}}
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==About this Structure==
==About this Structure==
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3OVS is a 4 chains structure with sequences from [http://en.wikipedia.org/wiki/Archaeoglobus_fulgidus Archaeoglobus fulgidus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OVS OCA].
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[[3ovs]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Archaeoglobus_fulgidus Archaeoglobus fulgidus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OVS OCA].
==Reference==
==Reference==
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<ref group="xtra">PMID:21071662</ref><references group="xtra"/>
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<ref group="xtra">PMID:021071662</ref><references group="xtra"/><references/>
[[Category: Archaeoglobus fulgidus]]
[[Category: Archaeoglobus fulgidus]]
[[Category: Pan, B C.]]
[[Category: Pan, B C.]]
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[[Category: Transferase-rna complex]]
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[[Category: Trna]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 1 11:35:06 2010''
 

Revision as of 08:36, 2 May 2013

Template:STRUCTURE 3ovs

Contents

How the CCA-adding Enzyme Selects Adenine over Cytosine in Position 76 of tRNA

Template:ABSTRACT PUBMED 21071662

Function

[CCA_ARCFU] Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate.[1]

About this Structure

3ovs is a 4 chain structure with sequence from Archaeoglobus fulgidus. Full crystallographic information is available from OCA.

Reference

  • Pan B, Xiong Y, Steitz TA. How the CCA-adding enzyme selects adenine over cytosine at position 76 of tRNA. Science. 2010 Nov 12;330(6006):937-40. PMID:21071662 doi:10.1126/science.1194985
  1. ↑ Okabe M, Tomita K, Ishitani R, Ishii R, Takeuchi N, Arisaka F, Nureki O, Yokoyama S. Divergent evolutions of trinucleotide polymerization revealed by an archaeal CCA-adding enzyme structure. EMBO J. 2003 Nov 3;22(21):5918-27. PMID:14592988 doi:http://dx.doi.org/10.1093/emboj/cdg563

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