3odr

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[[Image:3odr.png|left|200px]]
 
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{{STRUCTURE_3odr| PDB=3odr | SCENE= }}
{{STRUCTURE_3odr| PDB=3odr | SCENE= }}
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===Crystal Structure of the N-terminal Domain of Human Symplekin===
===Crystal Structure of the N-terminal Domain of Human Symplekin===
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{{ABSTRACT_PUBMED_20861839}}
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==Function==
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[[http://www.uniprot.org/uniprot/SYMPK_HUMAN SYMPK_HUMAN]] Scaffold protein that functions as a component of a multimolecular complex involved in histone mRNA 3'-end processing. Specific component of the tight junction (TJ) plaque, but might not be an exclusively junctional component. May have a house-keeping rule. Is involved in pre-mRNA polyadenylation. Enhances SSU72 phosphatase activity.<ref>PMID:16230528</ref> <ref>PMID:20861839</ref>
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{{ABSTRACT_PUBMED_20861839}}
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==About this Structure==
==About this Structure==
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3ODR is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ODR OCA].
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[[3odr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ODR OCA].
==Reference==
==Reference==
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<ref group="xtra">PMID:20861839</ref><references group="xtra"/>
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<ref group="xtra">PMID:020861839</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Tong, L.]]
[[Category: Tong, L.]]
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[[Category: Protein binding]]
[[Category: Protein binding]]
[[Category: Scaffold]]
[[Category: Scaffold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 20 06:12:13 2010''
 

Revision as of 08:38, 2 May 2013

Template:STRUCTURE 3odr

Contents

Crystal Structure of the N-terminal Domain of Human Symplekin

Template:ABSTRACT PUBMED 20861839

Function

[SYMPK_HUMAN] Scaffold protein that functions as a component of a multimolecular complex involved in histone mRNA 3'-end processing. Specific component of the tight junction (TJ) plaque, but might not be an exclusively junctional component. May have a house-keeping rule. Is involved in pre-mRNA polyadenylation. Enhances SSU72 phosphatase activity.[1] [2]

About this Structure

3odr is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Xiang K, Nagaike T, Xiang S, Kilic T, Beh MM, Manley JL, Tong L. Crystal structure of the human symplekin-Ssu72-CTD phosphopeptide complex. Nature. 2010 Sep 22. PMID:20861839 doi:10.1038/nature09391
  1. ↑ Kolev NG, Steitz JA. Symplekin and multiple other polyadenylation factors participate in 3'-end maturation of histone mRNAs. Genes Dev. 2005 Nov 1;19(21):2583-92. Epub 2005 Oct 17. PMID:16230528 doi:10.1101/gad.1371105
  2. ↑ Xiang K, Nagaike T, Xiang S, Kilic T, Beh MM, Manley JL, Tong L. Crystal structure of the human symplekin-Ssu72-CTD phosphopeptide complex. Nature. 2010 Sep 22. PMID:20861839 doi:10.1038/nature09391

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