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3of1

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Template:STRUCTURE 3of1

Contents

Crystal Structure of Bcy1, the Yeast Regulatory Subunit of PKA

Template:ABSTRACT PUBMED 21070946

Function

[KAPR_YEAST] Regulatory subunit of the cyclic AMP-dependent protein kinase (PKA), an effector of the Ras/cAMP pathway. Inhibits PKA activity in the absence of cAMP. cAMP activates PKA and promotes growth and proliferation in response to good nutrient conditions. Together with ZDS1, provides a negative feedback control on the cell wall integrity-signaling pathway by acting as a negative regulator of MAP kinase SLT2/MPK1.[1] [2] [3] [4]

About this Structure

3of1 is a 1 chain structure with sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

See Also

Reference

  • Rinaldi J, Wu J, Yang J, Ralston CY, Sankaran B, Moreno S, Taylor SS. Structure of yeast regulatory subunit: a glimpse into the evolution of PKA signaling. Structure. 2010 Nov 10;18(11):1471-82. PMID:21070946 doi:10.1016/j.str.2010.08.013
  1. ↑ Toda T, Cameron S, Sass P, Zoller M, Scott JD, McMullen B, Hurwitz M, Krebs EG, Wigler M. Cloning and characterization of BCY1, a locus encoding a regulatory subunit of the cyclic AMP-dependent protein kinase in Saccharomyces cerevisiae. Mol Cell Biol. 1987 Apr;7(4):1371-7. PMID:3037314
  2. ↑ Cannon JF, Tatchell K. Characterization of Saccharomyces cerevisiae genes encoding subunits of cyclic AMP-dependent protein kinase. Mol Cell Biol. 1987 Aug;7(8):2653-63. PMID:2823100
  3. ↑ Hixson CS, Krebs EG. Characterization of a cyclic AMP-binding protein from bakers' yeast. Identification as a regulatory subunit of cyclic AMP-dependent protein kinase. J Biol Chem. 1980 Mar 10;255(5):2137-45. PMID:6243658
  4. ↑ Griffioen G, Swinnen S, Thevelein JM. Feedback inhibition on cell wall integrity signaling by Zds1 involves Gsk3 phosphorylation of a cAMP-dependent protein kinase regulatory subunit. J Biol Chem. 2003 Jun 27;278(26):23460-71. Epub 2003 Apr 18. PMID:12704202 doi:10.1074/jbc.M210691200

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OCA

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