Sandbox Reserved 687

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==[[Emtricitabine]] (ECT)==
==[[Emtricitabine]] (ECT)==
[[Image:Emtricitabine3.png]]
[[Image:Emtricitabine3.png]]
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<Structure load='Insert PDB code or filename here' size='500' frame='true' align='right' caption='Insert caption here' scene='Insert optional scene name here' />
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<Structure load='ETV' size='500' frame='true' align='right' caption='[[Emtricitabine]] is an analog of cytidine and functions as antiretroviral drug (NRTI) for the treatment of HIV ' scene='Insert optional scene name here' />

Revision as of 20:52, 2 May 2013

This Sandbox is Reserved from 30/01/2013, through 30/12/2013 for use in the course "Biochemistry II" taught by Hannah Tims at the Messiah College. This reservation includes Sandbox Reserved 686 through Sandbox Reserved 700.
To get started:
  • Click the edit this page tab at the top. Save the page after each step, then edit it again.
  • Click the 3D button (when editing, above the wikitext box) to insert Jmol.
  • show the Scene authoring tools, create a molecular scene, and save it. Copy the green link into the page.
  • Add a description of your scene. Use the buttons above the wikitext box for bold, italics, links, headlines, etc.

More help: Help:Editing

Contents

Complera: Emtricitabine/rilpivirine/tenofovir

Upon infection, HIV binds to the CD4 receptor in a helper T cell or other CD4-presenting lymphocyte. The viral envelope is then fused with the cellular membrane allowing intracellular release of viral particles. The utilization of several enzymes helps to solidify the virus’s hold on the cell. HIV reverse transcriptase (RT) works to convert the viral single-stranded RNA (ssRNA) into DNA. HIV integrase then helps to incorporate the newly reverse transcribed DNA into the cellular genome. (Voet et al. 2008)


Rilpivirine (RPV)

Crystal structure of HIV-1 reverse transcriptase in complex with rilpivirine

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RPV in the In red are the binding pocket residues p66 (Leu-100, Lys-101, Lys-103, Val-106, Thr-107, Val-108, Val-179, Tyr-181, Tyr-188, Val-189, Gly-190, Phe-227, Trp-229, Leu- 234, and Tyr-318) and p51(Glu-138). Singh et al.

Tenofovir (TFV)

Image:Tenofovir.png

HIV-1 reverse transcriptase crosslinked to tenofovir terminated template-primer

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Reverse Transcriptase:

Emtricitabine (ECT)

Image:Emtricitabine3.png

Emtricitabine is an analog of cytidine and functions as antiretroviral drug (NRTI) for the treatment of HIV

Drag the structure with the mouse to rotate
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