Sandbox Reserved 686
From Proteopedia
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==Background== | ==Background== | ||
| - | Ivermectin is an important pharmaceutical, used mainly as an anti-helminthic agent. It is a macrocyclic lactone, evidenced by its structure above, and a member of the larger category of avermectins. One of the most common ways Ivermectin is used, is to treat Onchocerciasis. Onchocerciasis, better known as River Blindness, is the second leading cause of infectious blindness in the world. | + | Ivermectin is an important pharmaceutical, used mainly as an anti-helminthic agent. It is a macrocyclic lactone, evidenced by its structure above, and a member of the larger category of avermectins. Ivermectin was discovered from ''Streptomyces avermitilis''. One of the most common ways Ivermectin is used, is to treat Onchocerciasis. Onchocerciasis, better known as River Blindness, is the second leading cause of infectious blindness in the world. |
''O. volvulus'' and ''Wolbachia'' are the infectious agents involved in this disease. ''Wolbachia'', the bacterial symbiont of ''O. volvulus'', is released when the worm dies and causes inflammation and keratitis. Ivermectin work to kills the ''O. volvulus'' microfilariae and prevent the female macrofilariae from producing more microfilariae. The drug interacts with the glutamate-gated chloride channel to accomplish this. | ''O. volvulus'' and ''Wolbachia'' are the infectious agents involved in this disease. ''Wolbachia'', the bacterial symbiont of ''O. volvulus'', is released when the worm dies and causes inflammation and keratitis. Ivermectin work to kills the ''O. volvulus'' microfilariae and prevent the female macrofilariae from producing more microfilariae. The drug interacts with the glutamate-gated chloride channel to accomplish this. | ||
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==Mechanism== | ==Mechanism== | ||
| + | The <scene name='Sandbox_Reserved_686/Full_basic_protein_only_ivm/2'>glutamate-gated chloride channel</scene> is made up of <scene name='Sandbox_Reserved_686/5_subunits_no_fab_cl/2'>five homologous subunits</scene>, as displayed by the different colorings. All the subunits are conserved structurally, but not necessarily in their amino acid sequence. Each monomer has <scene name='Sandbox_Reserved_686/Full_basic_only_ivm_second_str/1'>two domains</scene>. | ||
| - | <scene name='Sandbox_Reserved_686/Full_basic_protein_only_ivm/2'>Protein structure as crystallized</scene> | ||
| - | <scene name='Sandbox_Reserved_686/5_subunits_no_fab_cl/2'>5 parts</scene> | ||
<scene name='Sandbox_Reserved_686/Ivm_between_2_subunits/1'>in between</scene> | <scene name='Sandbox_Reserved_686/Ivm_between_2_subunits/1'>in between</scene> | ||
| - | <scene name='Sandbox_Reserved_686/Full_basic_only_ivm_second_str/1'>Secondary Structure</scene> | ||
Revision as of 21:38, 3 May 2013
| This Sandbox is Reserved from 30/01/2013, through 30/12/2013 for use in the course "Biochemistry II" taught by Hannah Tims at the Messiah College. This reservation includes Sandbox Reserved 686 through Sandbox Reserved 700. |
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Ivermectin
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Background
Ivermectin is an important pharmaceutical, used mainly as an anti-helminthic agent. It is a macrocyclic lactone, evidenced by its structure above, and a member of the larger category of avermectins. Ivermectin was discovered from Streptomyces avermitilis. One of the most common ways Ivermectin is used, is to treat Onchocerciasis. Onchocerciasis, better known as River Blindness, is the second leading cause of infectious blindness in the world.
O. volvulus and Wolbachia are the infectious agents involved in this disease. Wolbachia, the bacterial symbiont of O. volvulus, is released when the worm dies and causes inflammation and keratitis. Ivermectin work to kills the O. volvulus microfilariae and prevent the female macrofilariae from producing more microfilariae. The drug interacts with the glutamate-gated chloride channel to accomplish this.
Mechanism
The is made up of , as displayed by the different colorings. All the subunits are conserved structurally, but not necessarily in their amino acid sequence. Each monomer has .
