We apologize for Proteopedia being slow to respond. For the past two years, a new implementation of Proteopedia has been being built. Soon, it will replace this 18-year old system. All existing content will be moved to the new system at a date that will be announced here.

Sandbox Reserved 695

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
(→Structure)
(→Introduction)
Line 10: Line 10:
STILL MAKING FINAL ADDITIONS
STILL MAKING FINAL ADDITIONS
-
Under normal circumstances, the voltage gated sodium channel, or (VGSC), serve to propagate the action potential down the axon, responding to elevated intracellular potential by opening the channel, allowing the rapid influx of sodium ions, which elevates the potential further, propagating the action potential. In a seizure, the synchronized activity of action potentials leads to very high frequency action potentials, leading to muscular convulsions and other symptoms <ref>McCormick DA, Contreras D. On the cellular and network bases of epileptic seizures. Annu Rev Physiol. 2001;63:815-46.</ref>. However, anticonvulsant drugs suppress seizures by limiting the high frequency firing of action potentials. These drugs do not interfere heavily with normal neurological activity, because they have little effect in neurons with normal resting potentials <ref>Rogawski, M., & Löscher, W. (2004). The neurobiology of antiepileptic drugs. Nature Reviews. Neuroscience, 5(7), 553-564.</ref>
+
Under normal circumstances, the voltage gated sodium channel, or (<scene name='Sandbox_Reserved_695/Vgsc_original/1'>VGSC</scene>), serve to propagate the action potential down the axon, responding to elevated intracellular potential by opening the channel, allowing the rapid influx of sodium ions, which elevates the potential further, propagating the action potential. In a seizure, the synchronized activity of action potentials leads to very high frequency action potentials, leading to muscular convulsions and other symptoms <ref>McCormick DA, Contreras D. On the cellular and network bases of epileptic seizures. Annu Rev Physiol. 2001;63:815-46.</ref>. However, anticonvulsant drugs suppress seizures by limiting the high frequency firing of action potentials. These drugs do not interfere heavily with normal neurological activity, because they have little effect in neurons with normal resting potentials <ref>Rogawski, M., & Löscher, W. (2004). The neurobiology of antiepileptic drugs. Nature Reviews. Neuroscience, 5(7), 553-564.</ref>
-
Structural determination of the <scene name='Sandbox_Reserved_695/Vgsc_original/1'>VGSC</scene> has revealed it to be composed of four homologous domains, each of which has six transmembrane regions, while the pore is composed of the S5 and S6 segments <ref>Sato C, Ueno Y, Asai K, Takahashi K, Sato M, Engel A, Fujiyoshi Y: The voltage-sensitive sodium channel is a bell-shaped molecule with several cavities. Nature 2001, 409:1047-1051.</ref>. For a better illustration of the structure, see [http://genomebiology.com/content/figures/gb-2003-4-3-207-1.jpg Schematic of Transmembrane regions of VGSC] <ref>F.H. Yu, W.A. Catterall Overview of the voltage-gated sodium channel superfamily Genome Biol., 4 (2003), pp. 207–214</ref>.
+
==Structure==
==Structure==

Revision as of 13:31, 4 May 2013

This Sandbox is Reserved from 30/01/2013, through 30/12/2013 for use in the course "Biochemistry II" taught by Hannah Tims at the Messiah College. This reservation includes Sandbox Reserved 686 through Sandbox Reserved 700.
To get started:
  • Click the edit this page tab at the top. Save the page after each step, then edit it again.
  • Click the 3D button (when editing, above the wikitext box) to insert Jmol.
  • show the Scene authoring tools, create a molecular scene, and save it. Copy the green link into the page.
  • Add a description of your scene. Use the buttons above the wikitext box for bold, italics, links, headlines, etc.

More help: Help:Editing

Contents

Epileptic drugs at Voltage-Gated Sodium Ion Channel

Insert caption here

Drag the structure with the mouse to rotate

Introduction

STILL MAKING FINAL ADDITIONS

Under normal circumstances, the voltage gated sodium channel, or (), serve to propagate the action potential down the axon, responding to elevated intracellular potential by opening the channel, allowing the rapid influx of sodium ions, which elevates the potential further, propagating the action potential. In a seizure, the synchronized activity of action potentials leads to very high frequency action potentials, leading to muscular convulsions and other symptoms [1]. However, anticonvulsant drugs suppress seizures by limiting the high frequency firing of action potentials. These drugs do not interfere heavily with normal neurological activity, because they have little effect in neurons with normal resting potentials [2]

Structure

The structure of the VGSC has four homologhous domains in vivo, however, for better illustration of the structures at work, the structure shown will only contain one subunit. The includes alpha helices (blue) and beta strands (red).

Interactions

Active Site

Mechanism

Inhibitors

Interactions/effectors

Other Stuff??

References

  1. ↑ McCormick DA, Contreras D. On the cellular and network bases of epileptic seizures. Annu Rev Physiol. 2001;63:815-46.
  2. ↑ Rogawski, M., & Löscher, W. (2004). The neurobiology of antiepileptic drugs. Nature Reviews. Neuroscience, 5(7), 553-564.

Original=



____/5 Background info ____/5 Structural elements ____Structure ____Description ____/5 Interactions ____Structure ____Description ____/5 Active site ____Structure ____Description ____/5 Mechanism ____Structure ____Description ____/5 Inhibitors ____Structure ____Description ____/5 Interactions/ effectors ___Structure ____Description ____ additional cool stuff. ____Structure ____Description

Retrieved from "http://52.214.119.220/wiki/index.php/Sandbox_Reserved_695"
Personal tools