This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
2fw3
From Proteopedia
(Difference between revisions)
(New page: 200px<br /><applet load="2fw3" size="450" color="white" frame="true" align="right" spinBox="true" caption="2fw3, resolution 2.50Å" /> '''Crystal structure of...) |
|||
| Line 1: | Line 1: | ||
| - | [[Image:2fw3.gif|left|200px]]<br /><applet load="2fw3" size=" | + | [[Image:2fw3.gif|left|200px]]<br /><applet load="2fw3" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="2fw3, resolution 2.50Å" /> | caption="2fw3, resolution 2.50Å" /> | ||
'''Crystal structure of rat carnitine palmitoyltransferase 2 in complex with antidiabetic drug ST1326'''<br /> | '''Crystal structure of rat carnitine palmitoyltransferase 2 in complex with antidiabetic drug ST1326'''<br /> | ||
==Overview== | ==Overview== | ||
| - | Carnitine palmitoyltransferases (CPTs) are part of the enzymatic system | + | Carnitine palmitoyltransferases (CPTs) are part of the enzymatic system that imports fatty acids into mitochondria. The crystal structure of rat CPT-2 by Rufer et al. (2006) (this issue of Structure) reveals a Y-shaped tunnel for binding the CoA and acyl-carnitine substrates and a hydrophobic insert mediating membrane association. |
==About this Structure== | ==About this Structure== | ||
| - | 2FW3 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] with BUI as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Carnitine_O-palmitoyltransferase Carnitine O-palmitoyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.21 2.3.1.21] Full crystallographic information is available from [http:// | + | 2FW3 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] with <scene name='pdbligand=BUI:'>BUI</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Carnitine_O-palmitoyltransferase Carnitine O-palmitoyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.21 2.3.1.21] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FW3 OCA]. |
==Reference== | ==Reference== | ||
| Line 14: | Line 14: | ||
[[Category: Rattus norvegicus]] | [[Category: Rattus norvegicus]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Banner, D | + | [[Category: Banner, D W.]] |
[[Category: Benz, J.]] | [[Category: Benz, J.]] | ||
[[Category: Chomienne, O.]] | [[Category: Chomienne, O.]] | ||
| Line 20: | Line 20: | ||
[[Category: Hennig, M.]] | [[Category: Hennig, M.]] | ||
[[Category: Mueller, F.]] | [[Category: Mueller, F.]] | ||
| - | [[Category: Roo, E | + | [[Category: Roo, E De.]] |
| - | [[Category: Rufer, A | + | [[Category: Rufer, A C.]] |
[[Category: Stihle, M.]] | [[Category: Stihle, M.]] | ||
[[Category: Thoma, R.]] | [[Category: Thoma, R.]] | ||
| Line 27: | Line 27: | ||
[[Category: central six-stranded beta-sheet]] | [[Category: central six-stranded beta-sheet]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:25:40 2008'' |
Revision as of 15:25, 21 February 2008
|
Crystal structure of rat carnitine palmitoyltransferase 2 in complex with antidiabetic drug ST1326
Overview
Carnitine palmitoyltransferases (CPTs) are part of the enzymatic system that imports fatty acids into mitochondria. The crystal structure of rat CPT-2 by Rufer et al. (2006) (this issue of Structure) reveals a Y-shaped tunnel for binding the CoA and acyl-carnitine substrates and a hydrophobic insert mediating membrane association.
About this Structure
2FW3 is a Single protein structure of sequence from Rattus norvegicus with as ligand. Active as Carnitine O-palmitoyltransferase, with EC number 2.3.1.21 Full crystallographic information is available from OCA.
Reference
A monotopic membrane protein goes solo., Mattevi A, Structure. 2006 Apr;14(4):628-9. PMID:16615901
Page seeded by OCA on Thu Feb 21 17:25:40 2008
