User:Samuel Carlson/Sandbox 1
From Proteopedia
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| - | + | =Bromodomain adjacent to zinc finger domain protein 2A (BAZ2a)= | |
<StructureSection load='3g0l' size='350' side='right' caption='Structure of BAZ2b bromodomain (PDB entry [[3g0l]]), BAZ2a similar' scene=''> | <StructureSection load='3g0l' size='350' side='right' caption='Structure of BAZ2b bromodomain (PDB entry [[3g0l]]), BAZ2a similar' scene=''> | ||
Anything in this section will appear adjacent to the 3D structure and will be scrollable. | Anything in this section will appear adjacent to the 3D structure and will be scrollable. | ||
</StructureSection> | </StructureSection> | ||
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| + | {{STRUCTURE_3g0l| PDB=3g0l | SCENE= }} | ||
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==Role in the Nucleolar Remodeling Complex (NoRC)== | ==Role in the Nucleolar Remodeling Complex (NoRC)== | ||
BAZ2A interacts with sucrose-nonfermenting protein 2 homolog (SNF2H) to form the NoRC, which recruits histone methyltransferases, histone deacetylases, and DNA methyltransferases. The NoRC silences transcription by modifying DNA compaction, as well as by interfering with ribosomal RNA (rRNA) transcription. (CITE) BAZ2a is thought to direct transcriptional repression by binding to histones labeled with posttranslational modifications (PTMs) such as acetylation on lysine residues. | BAZ2A interacts with sucrose-nonfermenting protein 2 homolog (SNF2H) to form the NoRC, which recruits histone methyltransferases, histone deacetylases, and DNA methyltransferases. The NoRC silences transcription by modifying DNA compaction, as well as by interfering with ribosomal RNA (rRNA) transcription. (CITE) BAZ2a is thought to direct transcriptional repression by binding to histones labeled with posttranslational modifications (PTMs) such as acetylation on lysine residues. | ||
| - | = BAZ2a Function= | + | ==Evolution and related structures== |
| + | The bromodomain of BAZ2a is highly conserved across | ||
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| + | =BAZ2a Function= | ||
==Role in Chromatin Remodeling== | ==Role in Chromatin Remodeling== | ||
Revision as of 03:57, 7 May 2013
Contents |
Bromodomain adjacent to zinc finger domain protein 2A (BAZ2a)
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| 3g0l, resolution 2.03Å () | |||||||||
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| Ligands: | |||||||||
| Gene: | BAZ2B (Homo sapiens) | ||||||||
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| Resources: | FirstGlance, OCA, RCSB, PDBsum | ||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||
Role in the Nucleolar Remodeling Complex (NoRC)
BAZ2A interacts with sucrose-nonfermenting protein 2 homolog (SNF2H) to form the NoRC, which recruits histone methyltransferases, histone deacetylases, and DNA methyltransferases. The NoRC silences transcription by modifying DNA compaction, as well as by interfering with ribosomal RNA (rRNA) transcription. (CITE) BAZ2a is thought to direct transcriptional repression by binding to histones labeled with posttranslational modifications (PTMs) such as acetylation on lysine residues.
Evolution and related structures
The bromodomain of BAZ2a is highly conserved across
BAZ2a Function
Role in Chromatin Remodeling
As a critical member of the NoRC, BAZ2a in conjunction with SNF2H is responsible for modifying the compaction of chromatin, through The NoRC is also responsible for ribosomal DNA (rDNA) transcription silencing, by recruiting histone deacetylase (HDAC) and DNA methyltransferase (DNMT) to the rDNA promoter, effectively creating a region with the characteristics of heterochromatin and silencing rDNA transcription. [1]
Medical Implications
References
- ↑ Santoro R, Li J, Grummt I. The nucleolar remodeling complex NoRC mediates heterochromatin formation and silencing of ribosomal gene transcription. Nat Genet. 2002 Nov;32(3):393-6. Epub 2002 Oct 7. PMID:12368916 doi:10.1038/ng1010
