2g1w

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(New page: 200px<br /><applet load="2g1w" size="350" color="white" frame="true" align="right" spinBox="true" caption="2g1w" /> '''NMR structure of the Aquifex aeolicus tmRNA ...)
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==Overview==
==Overview==
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The transfer-messenger RNA (tmRNA) pseudoknot PK1 is essential for, bacterial trans-translation, a ribosomal rescue mechanism. We report the, solution structure of PK1 from Aquifex aeolicus, which despite an, unprecedented small number of nucleotides and thus an unprecented compact, size, displays a very high thermal stability. Several unusual structural, features account for these properties and indicate that PK1 belongs to the, class of ribosomal frameshift pseudoknots. This suggests a similarity, between the mechanism of programmed ribosomal frameshifting and, trans-translation.
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The transfer-messenger RNA (tmRNA) pseudoknot PK1 is essential for bacterial trans-translation, a ribosomal rescue mechanism. We report the solution structure of PK1 from Aquifex aeolicus, which despite an unprecedented small number of nucleotides and thus an unprecented compact size, displays a very high thermal stability. Several unusual structural features account for these properties and indicate that PK1 belongs to the class of ribosomal frameshift pseudoknots. This suggests a similarity between the mechanism of programmed ribosomal frameshifting and trans-translation.
==About this Structure==
==About this Structure==
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[[Category: trans-translation]]
[[Category: trans-translation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jan 29 19:49:56 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:27:19 2008''

Revision as of 15:27, 21 February 2008

Image:2g1w.gif

2g1w

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NMR structure of the Aquifex aeolicus tmRNA pseudoknot PK1

Overview

The transfer-messenger RNA (tmRNA) pseudoknot PK1 is essential for bacterial trans-translation, a ribosomal rescue mechanism. We report the solution structure of PK1 from Aquifex aeolicus, which despite an unprecedented small number of nucleotides and thus an unprecented compact size, displays a very high thermal stability. Several unusual structural features account for these properties and indicate that PK1 belongs to the class of ribosomal frameshift pseudoknots. This suggests a similarity between the mechanism of programmed ribosomal frameshifting and trans-translation.

About this Structure

2G1W is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.

Reference

NMR structure of the Aquifex aeolicus tmRNA pseudoknot PK1: new insights into the recoding event of the ribosomal trans-translation., Nonin-Lecomte S, Felden B, Dardel F, Nucleic Acids Res. 2006 Apr 4;34(6):1847-53. Print 2006. PMID:16595798

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