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2c8u
From Proteopedia
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{{STRUCTURE_2c8u| PDB=2c8u | SCENE= }} | {{STRUCTURE_2c8u| PDB=2c8u | SCENE= }} | ||
| + | ===Structure of R21Q mutant of Sh28GST=== | ||
| + | {{ABSTRACT_PUBMED_16777141}} | ||
| - | === | + | ==Function== |
| - | + | [[http://www.uniprot.org/uniprot/GST28_SCHBO GST28_SCHBO]] Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. GST isoenzymes appear to play a central role in the parasite detoxification system. Other functions are also suspected including a role in increasing the solubility of haematin in the parasite gut. | |
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==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID:016777141</ref><references group="xtra"/> | + | <ref group="xtra">PMID:016777141</ref><references group="xtra"/><references/> |
[[Category: Glutathione transferase]] | [[Category: Glutathione transferase]] | ||
[[Category: Schistosoma haematobium]] | [[Category: Schistosoma haematobium]] | ||
Revision as of 06:39, 8 May 2013
Contents |
Structure of R21Q mutant of Sh28GST
Template:ABSTRACT PUBMED 16777141
Function
[GST28_SCHBO] Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. GST isoenzymes appear to play a central role in the parasite detoxification system. Other functions are also suspected including a role in increasing the solubility of haematin in the parasite gut.
About this Structure
2c8u is a 2 chain structure with sequence from Schistosoma haematobium. Full crystallographic information is available from OCA.
See Also
Reference
- Baiocco P, Gourlay LJ, Angelucci F, Fontaine J, Herve M, Miele AE, Trottein F, Brunori M, Bellelli A. Probing the mechanism of GSH activation in Schistosoma haematobium glutathione-S-transferase by site-directed mutagenesis and X-ray crystallography. J Mol Biol. 2006 Jul 14;360(3):678-89. Epub 2006 Jun 2. PMID:16777141 doi:10.1016/j.jmb.2006.05.040
