2m5b
From Proteopedia
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{{STRUCTURE_2m5b| PDB=2m5b | SCENE= }} | {{STRUCTURE_2m5b| PDB=2m5b | SCENE= }} | ||
===The NMR structure of the BID-BAK complex=== | ===The NMR structure of the BID-BAK complex=== | ||
| + | {{ABSTRACT_PUBMED_23604079}} | ||
==Function== | ==Function== | ||
Revision as of 06:56, 8 May 2013
Contents |
The NMR structure of the BID-BAK complex
Template:ABSTRACT PUBMED 23604079
Function
[BAK_HUMAN] In the presence of an appropriate stimulus, accelerates programmed cell death by binding to, and antagonizing the anti-apoptotic action of BCL2 or its adenovirus homolog E1B 19k protein. Low micromolar levels of zinc ions inhibit the promotion of apoptosis.[1] [2]
About this Structure
2m5b is a 2 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA.
Reference
- ↑ Chittenden T, Flemington C, Houghton AB, Ebb RG, Gallo GJ, Elangovan B, Chinnadurai G, Lutz RJ. A conserved domain in Bak, distinct from BH1 and BH2, mediates cell death and protein binding functions. EMBO J. 1995 Nov 15;14(22):5589-96. PMID:8521816
- ↑ Moldoveanu T, Liu Q, Tocilj A, Watson M, Shore G, Gehring K. The X-ray structure of a BAK homodimer reveals an inhibitory zinc binding site. Mol Cell. 2006 Dec 8;24(5):677-88. PMID:17157251 doi:10.1016/j.molcel.2006.10.014
