3qqp
From Proteopedia
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{{STRUCTURE_3qqp| PDB=3qqp | SCENE= }} | {{STRUCTURE_3qqp| PDB=3qqp | SCENE= }} | ||
===Crystal Structure of 11beta-Hydroxysteroid Dehydrogenase 1 (11b-HSD1) in Complex with Urea Inhibitor=== | ===Crystal Structure of 11beta-Hydroxysteroid Dehydrogenase 1 (11b-HSD1) in Complex with Urea Inhibitor=== | ||
| + | {{ABSTRACT_PUBMED_21439819}} | ||
==Disease== | ==Disease== | ||
Revision as of 06:57, 8 May 2013
Contents |
Crystal Structure of 11beta-Hydroxysteroid Dehydrogenase 1 (11b-HSD1) in Complex with Urea Inhibitor
Template:ABSTRACT PUBMED 21439819
Disease
[DHI1_HUMAN] Defects in HSD11B1 are a cause of cortisone reductase deficiency (CRD) [MIM:604931]. In CRD, activation of cortisone to cortisol does not occur, resulting in adrenocorticotropin-mediated androgen excess and a phenotype resembling polycystic ovary syndrome (PCOS).
Function
[DHI1_HUMAN] Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone. Catalyzes reversibly the conversion of 7-ketocholesterol to 7-beta-hydroxycholesterol. In intact cells, the reaction runs only in one direction, from 7-ketocholesterol to 7-beta-hydroxycholesterol (By similarity).
About this Structure
3qqp is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
