4fr3

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'''Unreleased structure'''
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{{STRUCTURE_4fr3| PDB=4fr3 | SCENE= }}
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===Crystal structure of human 14-3-3 sigma in complex with TASK-3 peptide and stabilizer 16-O-Me-FC-H===
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{{ABSTRACT_PUBMED_23601647}}
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The entry 4fr3 is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/1433S_HUMAN 1433S_HUMAN]] Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway (By similarity). p53-regulated inhibitor of G2/M progression.
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Authors: Ottmann, C., Anders, C., Schumacher, B.
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==About this Structure==
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[[4fr3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FR3 OCA].
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Description: Crystal structure of human 14-3-3 sigma in complex with TASK-3 peptide and stabilizer 16-O-Me-FC-H
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[[Category: Homo sapiens]]
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[[Category: Anders, C.]]
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[[Category: Ottmann, C.]]
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[[Category: Schumacher, B.]]
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[[Category: Nucleus]]
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[[Category: Peptide binding protein-toxin complex]]

Revision as of 07:40, 8 May 2013

Template:STRUCTURE 4fr3

Crystal structure of human 14-3-3 sigma in complex with TASK-3 peptide and stabilizer 16-O-Me-FC-H

Template:ABSTRACT PUBMED 23601647

Function

[1433S_HUMAN] Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway (By similarity). p53-regulated inhibitor of G2/M progression.

About this Structure

4fr3 is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

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OCA

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