4jr5

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m (Protected "4jr5" [edit=sysop:move=sysop])
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'''Unreleased structure'''
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{{STRUCTURE_4jr5| PDB=4jr5 | SCENE= }}
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===Structure-based Identification of Ureas as Novel Nicotinamide Phosphoribosyltransferase (Nampt) Inhibitors===
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{{ABSTRACT_PUBMED_23617784}}
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The entry 4jr5 is ON HOLD
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==Function==
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[[http://www.uniprot.org/uniprot/NAMPT_HUMAN NAMPT_HUMAN]] Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway (By similarity).
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Authors: Zheng, X., Bauer, P., Baumeister, T., Buckmelter, A.J., Caligiuri, M., Clodfelter, K.H., Han, B., Ho, Y., Kley, N., Lin, J., Reynolds, D.J., Sharma, G., Smith, C.C., Wang, Z., Dragovich, P.S., Oh, A., Wang, W., Zak, M., Gunzner-Toste, J., Zhao, G., Yuen, P., Bair, K.W.
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==About this Structure==
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[[4jr5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JR5 OCA].
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Description: Structure-based Identification of Ureas as Novel Nicotinamide Phosphoribosyltransferase (Nampt) Inhibitors
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[[Category: Homo sapiens]]
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[[Category: Nicotinamide phosphoribosyltransferase]]
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[[Category: Bair, K W.]]
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[[Category: Bauer, P.]]
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[[Category: Baumeister, T.]]
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[[Category: Buckmelter, A J.]]
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[[Category: Caligiuri, M.]]
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[[Category: Clodfelter, K H.]]
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[[Category: Dragovich, P S.]]
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[[Category: Gunzner-Toste, J.]]
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[[Category: Han, B.]]
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[[Category: Ho, Y.]]
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[[Category: Kley, N.]]
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[[Category: Lin, J.]]
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[[Category: Oh, A.]]
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[[Category: Reynolds, D J.]]
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[[Category: Sharma, G.]]
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[[Category: Smith, C C.]]
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[[Category: Wang, W.]]
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[[Category: Wang, Z.]]
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[[Category: Yuen, P.]]
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[[Category: Zak, M.]]
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[[Category: Zhao, G.]]
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[[Category: Zheng, X.]]
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[[Category: Transferase-transferase inhibitor complex]]

Revision as of 07:43, 8 May 2013

Template:STRUCTURE 4jr5

Structure-based Identification of Ureas as Novel Nicotinamide Phosphoribosyltransferase (Nampt) Inhibitors

Template:ABSTRACT PUBMED 23617784

Function

[NAMPT_HUMAN] Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway (By similarity).

About this Structure

4jr5 is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

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OCA

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