4ga3

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'''Unreleased structure'''
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{{STRUCTURE_4ga3| PDB=4ga3 | SCENE= }}
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===Crystal Structure of Human Farnesyl Diphosphate Synthase in Complex with BPH-1260===
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{{ABSTRACT_PUBMED_23610597}}
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The entry 4ga3 is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/FPPS_HUMAN FPPS_HUMAN]] Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.
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Authors: Liu, Y.-L., Zhang, Y., Oldfield, E.
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==About this Structure==
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[[4ga3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GA3 OCA].
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Description: Crystal Structure of Human Farnesyl Diphosphate Synthase in Complex with BPH-1260
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[[Category: Homo sapiens]]
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[[Category: Liu, Y L.]]
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[[Category: Oldfield, E.]]
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[[Category: Zhang, Y.]]
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[[Category: All alpha helice]]
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[[Category: Cytosol]]
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[[Category: Transferase]]

Revision as of 07:45, 8 May 2013

Template:STRUCTURE 4ga3

Crystal Structure of Human Farnesyl Diphosphate Synthase in Complex with BPH-1260

Template:ABSTRACT PUBMED 23610597

Function

[FPPS_HUMAN] Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.

About this Structure

4ga3 is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

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OCA

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