This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
4ga3
From Proteopedia
| Line 1: | Line 1: | ||
| - | + | {{STRUCTURE_4ga3| PDB=4ga3 | SCENE= }} | |
| + | ===Crystal Structure of Human Farnesyl Diphosphate Synthase in Complex with BPH-1260=== | ||
| + | {{ABSTRACT_PUBMED_23610597}} | ||
| - | + | ==Function== | |
| + | [[http://www.uniprot.org/uniprot/FPPS_HUMAN FPPS_HUMAN]] Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate. | ||
| - | + | ==About this Structure== | |
| - | + | [[4ga3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GA3 OCA]. | |
| - | + | [[Category: Homo sapiens]] | |
| + | [[Category: Liu, Y L.]] | ||
| + | [[Category: Oldfield, E.]] | ||
| + | [[Category: Zhang, Y.]] | ||
| + | [[Category: All alpha helice]] | ||
| + | [[Category: Cytosol]] | ||
| + | [[Category: Transferase]] | ||
Revision as of 07:45, 8 May 2013
Crystal Structure of Human Farnesyl Diphosphate Synthase in Complex with BPH-1260
Template:ABSTRACT PUBMED 23610597
Function
[FPPS_HUMAN] Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.
About this Structure
4ga3 is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
