4kfo
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(New page: {{STRUCTURE_4kfo| PDB=4kfo | SCENE= }} ===Structure-Based Discovery of Novel Amide-Containing Nicotinamide Phosphoribosyltransferase (Nampt) Inhibitors=== {{ABSTRACT_PUBMED_23617784}}...)
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Revision as of 07:45, 8 May 2013
Structure-Based Discovery of Novel Amide-Containing Nicotinamide Phosphoribosyltransferase (Nampt) Inhibitors
Template:ABSTRACT PUBMED 23617784
Function
[NAMPT_HUMAN] Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway (By similarity).
About this Structure
4kfo is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Categories: Homo sapiens | Nicotinamide phosphoribosyltransferase | Bair, K W. | Bauer, P. | Baumeister, T. | Brien, T O. | Buckmelter, A J. | Caligiuri, M. | Clodfelter, K H. | Dragovich, P S. | Gunzner-Tosteb, J. | Han, B. | Ho, Y. | Kley, N. | Liederer, B M. | Lin, J. | Ly, J. | Oh, A. | Reynolds, D J. | Sharma, G. | Smith, C C. | Wang, L. | Wang, W. | Wang, Z. | Xiao, Y. | Yuen, P. | Zak, M. | Zhao, G. | Zheng, X. | Transferase-transferase inhibitor complex
