3vzc

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'''Unreleased structure'''
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{{STRUCTURE_3vzc| PDB=3vzc | SCENE= }}
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===Crystal structure of Sphingosine Kinase 1 with inhibitor===
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{{ABSTRACT_PUBMED_23602659}}
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The entry 3vzc is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/SPHK1_HUMAN SPHK1_HUMAN]] Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro-sphingosine and to a lesser extent sphinganine, but not other lipids, such as D,L-threo-dihydrosphingosine, N,N-dimethylsphingosine, diacylglycerol, ceramide, or phosphatidylinositol.<ref>PMID:20577214</ref>
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Authors: Min, X., Walker, N.P., Wang, Z.
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==About this Structure==
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[[3vzc]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VZC OCA].
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Description: Crystal structure of a kinase with inhibitor
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Homo sapiens]]
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[[Category: Sphinganine kinase]]
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[[Category: Min, X.]]
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[[Category: Walker, N P.]]
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[[Category: Wang, Z.]]
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[[Category: Lipid kinase]]
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[[Category: Transferase-inhibitor complex]]

Revision as of 07:46, 8 May 2013

Template:STRUCTURE 3vzc

Contents

Crystal structure of Sphingosine Kinase 1 with inhibitor

Template:ABSTRACT PUBMED 23602659

Function

[SPHK1_HUMAN] Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro-sphingosine and to a lesser extent sphinganine, but not other lipids, such as D,L-threo-dihydrosphingosine, N,N-dimethylsphingosine, diacylglycerol, ceramide, or phosphatidylinositol.[1]

About this Structure

3vzc is a 6 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  1. ↑ Alvarez SE, Harikumar KB, Hait NC, Allegood J, Strub GM, Kim EY, Maceyka M, Jiang H, Luo C, Kordula T, Milstien S, Spiegel S. Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2. Nature. 2010 Jun 24;465(7301):1084-8. doi: 10.1038/nature09128. PMID:20577214 doi:10.1038/nature09128

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