4bhp

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'''Unreleased structure'''
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{{STRUCTURE_4bhp| PDB=4bhp | SCENE= }}
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===A structural model of CAP mutant (T127L and S128I) in cGMP-bound state===
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The entry 4bhp is ON HOLD until Apr 04 2015
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==Function==
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[[http://www.uniprot.org/uniprot/CRP_ECOLI CRP_ECOLI]] This protein complexes with cyclic AMP and binds to specific DNA sites near the promoter to regulate the transcription of several catabolite-sensitive operons. The protein induces a severe bend in the DNA. Acts as a negative regulator of its own synthesis as well as for adenylate cyclase (cyaA), which generates cAMP.<ref>PMID:2982847</ref>
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Authors: Tzeng, S.R., Kalodimos, C.G.
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==About this Structure==
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[[4bhp]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BHP OCA].
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Description: A structural model of CAP mutant (T127L and S128I) in cGMP-bound state
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Escherichia coli]]
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[[Category: Kalodimos, C G.]]
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[[Category: Tzeng, S R.]]
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[[Category: Transcription]]

Revision as of 07:48, 8 May 2013

Template:STRUCTURE 4bhp

Contents

A structural model of CAP mutant (T127L and S128I) in cGMP-bound state

Function

[CRP_ECOLI] This protein complexes with cyclic AMP and binds to specific DNA sites near the promoter to regulate the transcription of several catabolite-sensitive operons. The protein induces a severe bend in the DNA. Acts as a negative regulator of its own synthesis as well as for adenylate cyclase (cyaA), which generates cAMP.[1]

About this Structure

4bhp is a 1 chain structure with sequence from Escherichia coli. Full experimental information is available from OCA.

Reference

  1. ↑ Aiba H. Transcription of the Escherichia coli adenylate cyclase gene is negatively regulated by cAMP-cAMP receptor protein. J Biol Chem. 1985 Mar 10;260(5):3063-70. PMID:2982847

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