4ez1

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'''Unreleased structure'''
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{{STRUCTURE_4ez1| PDB=4ez1 | SCENE= }}
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===Crystal structure of acetylcholine binding protein (AChBP) from Aplysia Californica in complex with alpha-conotoxin BuIA===
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The entry 4ez1 is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/CA1A_CONBU CA1A_CONBU]] Alpha-conotoxins bind to the nicotinic acetylcholine receptors (nAChR) and inhibit them. This peptide potently blocks numerous mammalian nAChR subtypes (alpha-6 or -3/beta-2 or -3 > alpha-6 or-3/beta-4 > alpha-3/beta-2 > alpha-3/beta-4 > alpha-4/beta-4 = alpha-2/beta-4 > alpha-7 > alpha-2/beta-2 >> alpha-4/beta-2). Recovery from toxin block is markedly slower for beta-4 versus beta-2 subunit-containing nAChRs. Thus, it represents a novel probe for distinguishing between beta-2 and beta-4-containing nAChRs.
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Authors: Talley, T.T., Reger, A.S., Kim, C., Sankaran, B., Ho, K., Taylor, P., McIntosh, J.M.
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==About this Structure==
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[[4ez1]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Aplysia_californica Aplysia californica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EZ1 OCA].
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Description: Crystal structure of acetylcholine binding protein (AChBP) from Aplysia Californica in complex with alpha-conotoxin BuIA
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[[Category: Aplysia californica]]
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[[Category: Ho, K.]]
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[[Category: Kim, C.]]
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[[Category: McIntosh, J M.]]
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[[Category: Reger, A S.]]
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[[Category: Sankaran, B.]]
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[[Category: Talley, T T.]]
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[[Category: Taylor, P.]]
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[[Category: Choline binding protein-toxin complex]]

Revision as of 07:49, 8 May 2013

Template:STRUCTURE 4ez1

Crystal structure of acetylcholine binding protein (AChBP) from Aplysia Californica in complex with alpha-conotoxin BuIA

Function

[CA1A_CONBU] Alpha-conotoxins bind to the nicotinic acetylcholine receptors (nAChR) and inhibit them. This peptide potently blocks numerous mammalian nAChR subtypes (alpha-6 or -3/beta-2 or -3 > alpha-6 or-3/beta-4 > alpha-3/beta-2 > alpha-3/beta-4 > alpha-4/beta-4 = alpha-2/beta-4 > alpha-7 > alpha-2/beta-2 >> alpha-4/beta-2). Recovery from toxin block is markedly slower for beta-4 versus beta-2 subunit-containing nAChRs. Thus, it represents a novel probe for distinguishing between beta-2 and beta-4-containing nAChRs.

About this Structure

4ez1 is a 10 chain structure with sequence from Aplysia californica. Full crystallographic information is available from OCA.

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OCA

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