4geg

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'''Unreleased structure'''
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{{STRUCTURE_4geg| PDB=4geg | SCENE= }}
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===Crystal Structure of E.coli MenH Y85F Mutant===
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The entry 4geg is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/MENH_ECOLI MENH_ECOLI]] Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro.<ref>PMID:15808744</ref> <ref>PMID:18284213</ref>
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Authors: Johnston, J.M, Baker, E.N., Guo, Z., Jiang, M.
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==About this Structure==
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[[4geg]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_k-12 Escherichia coli k-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GEG OCA].
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Description: Crystal Structure of E.coli MenH Y85F Mutant
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==Reference==
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<references group="xtra"/><references/>
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[[Category: 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase]]
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[[Category: Escherichia coli k-12]]
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[[Category: Baker, E N.]]
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[[Category: Guo, Z.]]
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[[Category: Jiang, M.]]
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[[Category: Johnston, J M]]
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[[Category: 2-succinyl-6-hydroxy-2]]
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[[Category: 4-cyclohexadiene-1-carboxylate synthase]]
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[[Category: Alpha beta hydrolase]]
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[[Category: Lyase]]
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[[Category: Menaquinone biosynthesis]]
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[[Category: Menh y85f mutant]]

Revision as of 07:52, 8 May 2013

Template:STRUCTURE 4geg

Contents

Crystal Structure of E.coli MenH Y85F Mutant

Function

[MENH_ECOLI] Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro.[1] [2]

About this Structure

4geg is a 3 chain structure with sequence from Escherichia coli k-12. Full crystallographic information is available from OCA.

Reference

  1. ↑ Kuznetsova E, Proudfoot M, Sanders SA, Reinking J, Savchenko A, Arrowsmith CH, Edwards AM, Yakunin AF. Enzyme genomics: Application of general enzymatic screens to discover new enzymes. FEMS Microbiol Rev. 2005 Apr;29(2):263-79. PMID:15808744 doi:S0168-6445(05)00004-5
  2. ↑ Jiang M, Chen X, Guo ZF, Cao Y, Chen M, Guo Z. Identification and characterization of (1R,6R)-2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase in the menaquinone biosynthesis of Escherichia coli. Biochemistry. 2008 Mar 18;47(11):3426-34. doi: 10.1021/bi7023755. Epub 2008 Feb, 20. PMID:18284213 doi:10.1021/bi7023755

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