4j8s

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'''Unreleased structure'''
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{{STRUCTURE_4j8s| PDB=4j8s | SCENE= }}
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===Crystal structure of human CNOT1 MIF4G domain in complex with a TTP peptide===
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The entry 4j8s is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/CNOT1_HUMAN CNOT1_HUMAN]] Belongs to the CCR4-NOT complex that functions as general transcription regulation complex. Acts as a transcriptional repressor. Represses the ligand-dependent transcriptional activation by nuclear receptors.<ref>PMID:10637334</ref> <ref>PMID:16778766</ref> [[http://www.uniprot.org/uniprot/TTP_HUMAN TTP_HUMAN]] mRNA-binding protein involved in post-transcriptional regulation of AU-rich element (ARE)-containing mRNAs. Acts by specifically binding ARE-containing mRNAs and promoting their degradation. Plays a key role in the post-transcriptional regulation of tumor necrosis factor (TNF).<ref>PMID:15014438</ref>
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Authors: Frank, F., Fabian, M.R., Rouya, C., Siddiqui, N., Lai, W.S., Karetnikov, A., Blackshear, P.J., Sonenberg. N., Nagar, B.
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==About this Structure==
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[[4j8s]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J8S OCA].
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Description: Crystal structure of human CNOT1 MIF4G domain in complex with a TTP peptide
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Homo sapiens]]
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[[Category: Blackshear, P J.]]
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[[Category: Fabian, M R.]]
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[[Category: Frank, F.]]
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[[Category: Karetnikov, A.]]
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[[Category: Lai, W S.]]
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[[Category: Nagar, B.]]
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[[Category: Rouya, C.]]
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[[Category: Siddiqui, N.]]
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[[Category: Sonenberg, N.]]
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[[Category: Cytosol]]
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[[Category: Mif4g]]
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[[Category: Protein binding]]
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[[Category: Protein-protein interaction]]
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[[Category: Ttp]]

Revision as of 07:55, 8 May 2013

Template:STRUCTURE 4j8s

Contents

Crystal structure of human CNOT1 MIF4G domain in complex with a TTP peptide

Function

[CNOT1_HUMAN] Belongs to the CCR4-NOT complex that functions as general transcription regulation complex. Acts as a transcriptional repressor. Represses the ligand-dependent transcriptional activation by nuclear receptors.[1] [2] [TTP_HUMAN] mRNA-binding protein involved in post-transcriptional regulation of AU-rich element (ARE)-containing mRNAs. Acts by specifically binding ARE-containing mRNAs and promoting their degradation. Plays a key role in the post-transcriptional regulation of tumor necrosis factor (TNF).[3]

About this Structure

4j8s is a 2 chain structure with sequence from [1] and Homo sapiens. Full crystallographic information is available from OCA.

Reference

  1. ↑ Albert TK, Lemaire M, van Berkum NL, Gentz R, Collart MA, Timmers HT. Isolation and characterization of human orthologs of yeast CCR4-NOT complex subunits. Nucleic Acids Res. 2000 Feb 1;28(3):809-17. PMID:10637334
  2. ↑ Winkler GS, Mulder KW, Bardwell VJ, Kalkhoven E, Timmers HT. Human Ccr4-Not complex is a ligand-dependent repressor of nuclear receptor-mediated transcription. EMBO J. 2006 Jul 12;25(13):3089-99. Epub 2006 Jun 15. PMID:16778766 doi:7601194
  3. ↑ Stoecklin G, Stubbs T, Kedersha N, Wax S, Rigby WF, Blackwell TK, Anderson P. MK2-induced tristetraprolin:14-3-3 complexes prevent stress granule association and ARE-mRNA decay. EMBO J. 2004 Mar 24;23(6):1313-24. Epub 2004 Mar 11. PMID:15014438 doi:10.1038/sj.emboj.7600163

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