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4jr2

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'''Unreleased structure'''
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{{STRUCTURE_4jr2| PDB=4jr2 | SCENE= }}
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===Human procaspase-7/caspase-7 heterodimer bound to Ac-DEVD-CMK===
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The entry 4jr2 is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/CASP7_HUMAN CASP7_HUMAN]] Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Overexpression promotes programmed cell death.
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Authors: Thomsen, N.D., Wells, J.A.
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==About this Structure==
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[[4jr2]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JR2 OCA].
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Description:
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[[Category: Caspase-7]]
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[[Category: Homo sapiens]]
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[[Category: Thomsen, N D.]]
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[[Category: Wells, J A.]]
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[[Category: Activity based probe]]
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[[Category: Apoptosis]]
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[[Category: Caspase]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Irreversible inhibitor]]
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[[Category: Proenzyme]]
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[[Category: Protease]]
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[[Category: Protein-peptide complex]]

Revision as of 07:56, 8 May 2013

Template:STRUCTURE 4jr2

Human procaspase-7/caspase-7 heterodimer bound to Ac-DEVD-CMK

Function

[CASP7_HUMAN] Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Overexpression promotes programmed cell death.

About this Structure

4jr2 is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

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OCA

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