4jr2
From Proteopedia
(Difference between revisions)
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| - | + | {{STRUCTURE_4jr2| PDB=4jr2 | SCENE= }} | |
| + | ===Human procaspase-7/caspase-7 heterodimer bound to Ac-DEVD-CMK=== | ||
| - | + | ==Function== | |
| + | [[http://www.uniprot.org/uniprot/CASP7_HUMAN CASP7_HUMAN]] Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Overexpression promotes programmed cell death. | ||
| - | + | ==About this Structure== | |
| - | + | [[4jr2]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JR2 OCA]. | |
| - | + | [[Category: Caspase-7]] | |
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Thomsen, N D.]] | ||
| + | [[Category: Wells, J A.]] | ||
| + | [[Category: Activity based probe]] | ||
| + | [[Category: Apoptosis]] | ||
| + | [[Category: Caspase]] | ||
| + | [[Category: Hydrolase-hydrolase inhibitor complex]] | ||
| + | [[Category: Irreversible inhibitor]] | ||
| + | [[Category: Proenzyme]] | ||
| + | [[Category: Protease]] | ||
| + | [[Category: Protein-peptide complex]] | ||
Revision as of 07:56, 8 May 2013
Human procaspase-7/caspase-7 heterodimer bound to Ac-DEVD-CMK
Function
[CASP7_HUMAN] Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Overexpression promotes programmed cell death.
About this Structure
4jr2 is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
