3phm

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[[Image:3phm.png|left|200px]]
 
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{{STRUCTURE_3phm| PDB=3phm | SCENE= }}
{{STRUCTURE_3phm| PDB=3phm | SCENE= }}
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===REDUCED (CU+) PEPTIDYLGLYCINE ALPHA-HYDROXYLATING MONOOXYGENASE (PHM)===
===REDUCED (CU+) PEPTIDYLGLYCINE ALPHA-HYDROXYLATING MONOOXYGENASE (PHM)===
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{{ABSTRACT_PUBMED_10504734}}
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==Function==
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[[http://www.uniprot.org/uniprot/AMD_RAT AMD_RAT]] Bifunctional enzyme that catalyzes 2 sequential steps in C-terminal alpha-amidation of peptides. The monooxygenase part produces an unstable peptidyl(2-hydroxyglycine) intermediate that is dismutated to glyoxylate and the corresponding desglycine peptide amide by the lyase part. C-terminal amidation of peptides such as neuropeptides is essential for full biological activity.
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{{ABSTRACT_PUBMED_10504734}}
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==About this Structure==
==About this Structure==
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3PHM is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PHM OCA].
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[[3phm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PHM OCA].
==Reference==
==Reference==
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<ref group="xtra">PMID:10504734</ref><references group="xtra"/>
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<ref group="xtra">PMID:010504734</ref><references group="xtra"/><references/>
[[Category: Peptidylglycine monooxygenase]]
[[Category: Peptidylglycine monooxygenase]]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: Ascorbate]]
[[Category: Ascorbate]]
[[Category: Bioactive peptide activation]]
[[Category: Bioactive peptide activation]]
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[[Category: Copper]]
 
[[Category: Monooxygenase]]
[[Category: Monooxygenase]]
[[Category: Oxidoreductase]]
[[Category: Oxidoreductase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 12:19:18 2009''
 

Revision as of 08:07, 8 May 2013

Template:STRUCTURE 3phm

Contents

REDUCED (CU+) PEPTIDYLGLYCINE ALPHA-HYDROXYLATING MONOOXYGENASE (PHM)

Template:ABSTRACT PUBMED 10504734

Function

[AMD_RAT] Bifunctional enzyme that catalyzes 2 sequential steps in C-terminal alpha-amidation of peptides. The monooxygenase part produces an unstable peptidyl(2-hydroxyglycine) intermediate that is dismutated to glyoxylate and the corresponding desglycine peptide amide by the lyase part. C-terminal amidation of peptides such as neuropeptides is essential for full biological activity.

About this Structure

3phm is a 1 chain structure with sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

  • Prigge ST, Kolhekar AS, Eipper BA, Mains RE, Amzel LM. Substrate-mediated electron transfer in peptidylglycine alpha-hydroxylating monooxygenase. Nat Struct Biol. 1999 Oct;6(10):976-83. PMID:10504734 doi:10.1038/13351

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