3q93
From Proteopedia
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{{STRUCTURE_3q93| PDB=3q93 | SCENE= }} | {{STRUCTURE_3q93| PDB=3q93 | SCENE= }} | ||
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===Crystal Structure of Human 8-oxo-dGTPase (MTH1)=== | ===Crystal Structure of Human 8-oxo-dGTPase (MTH1)=== | ||
| + | ==Function== | ||
| + | [[http://www.uniprot.org/uniprot/8ODP_HUMAN 8ODP_HUMAN]] Antimutagenic. Acts as a sanitizing enzyme for oxidized nucleotide pools, thus suppressing cell dysfunction and death induced by oxidative stress. Hydrolyzes 8-oxo-dGTP, 8-oxo-dATP and 2-OH-dATP, thus preventing misincorporation of oxidized purine nucleoside triphosphates into DNA and subsequently preventing A:T to C:G and G:C to T:A transversions. Able to hydrolyze also the corresponding ribonucleotides, 2-OH-ATP, 8-oxo-GTP and 8-oxo-ATP.<ref>PMID:10373420</ref> <ref>PMID:10608900</ref> <ref>PMID:11139615</ref> <ref>PMID:12857738</ref> <ref>PMID:22556419</ref> | ||
==About this Structure== | ==About this Structure== | ||
[[3q93]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q93 OCA]. | [[3q93]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q93 OCA]. | ||
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| + | ==Reference== | ||
| + | <references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Arrowsmith, C H.]] | [[Category: Arrowsmith, C H.]] | ||
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[[Category: Weigelt, J.]] | [[Category: Weigelt, J.]] | ||
[[Category: Welin, M.]] | [[Category: Welin, M.]] | ||
| + | [[Category: Hydrolase]] | ||
| + | [[Category: Magnesium binding]] | ||
| + | [[Category: Mutt-like]] | ||
| + | [[Category: Nudix]] | ||
| + | [[Category: Sgc]] | ||
| + | [[Category: Structural genomic]] | ||
| + | [[Category: Structural genomics consortium]] | ||
Revision as of 08:10, 8 May 2013
Contents |
Crystal Structure of Human 8-oxo-dGTPase (MTH1)
Function
[8ODP_HUMAN] Antimutagenic. Acts as a sanitizing enzyme for oxidized nucleotide pools, thus suppressing cell dysfunction and death induced by oxidative stress. Hydrolyzes 8-oxo-dGTP, 8-oxo-dATP and 2-OH-dATP, thus preventing misincorporation of oxidized purine nucleoside triphosphates into DNA and subsequently preventing A:T to C:G and G:C to T:A transversions. Able to hydrolyze also the corresponding ribonucleotides, 2-OH-ATP, 8-oxo-GTP and 8-oxo-ATP.[1] [2] [3] [4] [5]
About this Structure
3q93 is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- ↑ Fujikawa K, Kamiya H, Yakushiji H, Fujii Y, Nakabeppu Y, Kasai H. The oxidized forms of dATP are substrates for the human MutT homologue, the hMTH1 protein. J Biol Chem. 1999 Jun 25;274(26):18201-5. PMID:10373420
- ↑ Fujii Y, Shimokawa H, Sekiguchi M, Nakabeppu Y. Functional significance of the conserved residues for the 23-residue module among MTH1 and MutT family proteins. J Biol Chem. 1999 Dec 31;274(53):38251-9. PMID:10608900
- ↑ Fujikawa K, Kamiya H, Yakushiji H, Nakabeppu Y, Kasai H. Human MTH1 protein hydrolyzes the oxidized ribonucleotide, 2-hydroxy-ATP. Nucleic Acids Res. 2001 Jan 15;29(2):449-54. PMID:11139615
- ↑ Yoshimura D, Sakumi K, Ohno M, Sakai Y, Furuichi M, Iwai S, Nakabeppu Y. An oxidized purine nucleoside triphosphatase, MTH1, suppresses cell death caused by oxidative stress. J Biol Chem. 2003 Sep 26;278(39):37965-73. Epub 2003 Jul 10. PMID:12857738 doi:10.1074/jbc.M306201200
- ↑ Takagi Y, Setoyama D, Ito R, Kamiya H, Yamagata Y, Sekiguchi M. Human MTH3 (NUDT18) protein hydrolyzes oxidized forms of guanosine and deoxyguanosine diphosphates: comparison with MTH1 and MTH2. J Biol Chem. 2012 Jun 15;287(25):21541-9. doi: 10.1074/jbc.M112.363010. Epub 2012, May 3. PMID:22556419 doi:10.1074/jbc.M112.363010
Categories: Homo sapiens | Arrowsmith, C H. | Berg, S Van Der. | Berglund, H. | Bountra, C. | Collins, R. | Edwards, A M. | Ekblad, T. | Flodin, S. | Flores, A. | Graslund, S. | Hammarstrom, M. | Johansson, I. | Karlberg, T. | Kol, S. | Kotenyova, T. | Kouznetsova, E. | Moche, M. | Nordlund, P. | Nyman, T. | Persson, C. | SGC, Structural Genomics Consortium. | Schuler, H. | Schutz, P. | Siponen, M I. | Thorsell, A G. | Tresaugues, L. | Wahlberg, E. | Weigelt, J. | Welin, M. | Hydrolase | Magnesium binding | Mutt-like | Nudix | Sgc | Structural genomic | Structural genomics consortium
