2wks
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | [[Image:2wks.png|left|200px]] | ||
| - | |||
| - | <!-- | ||
| - | The line below this paragraph, containing "STRUCTURE_2wks", creates the "Structure Box" on the page. | ||
| - | You may change the PDB parameter (which sets the PDB file loaded into the applet) | ||
| - | or the SCENE parameter (which sets the initial scene displayed when the page is loaded), | ||
| - | or leave the SCENE parameter empty for the default display. | ||
| - | --> | ||
{{STRUCTURE_2wks| PDB=2wks | SCENE= }} | {{STRUCTURE_2wks| PDB=2wks | SCENE= }} | ||
| - | |||
===STRUCTURE OF HELICOBACTER PYLORI TYPE II DEHYDROQUINASE WITH A NEW CARBASUGAR-THIOPHENE INHIBITOR.=== | ===STRUCTURE OF HELICOBACTER PYLORI TYPE II DEHYDROQUINASE WITH A NEW CARBASUGAR-THIOPHENE INHIBITOR.=== | ||
| + | {{ABSTRACT_PUBMED_19911771}} | ||
| - | + | ==Function== | |
| - | + | [[http://www.uniprot.org/uniprot/AROQ_HELPY AROQ_HELPY]] Catalyzes a trans-dehydration via an enolate intermediate (By similarity).[HAMAP-Rule:MF_00169] | |
| - | + | ||
| - | + | ||
| - | - | + | |
| - | + | ||
==About this Structure== | ==About this Structure== | ||
| Line 22: | Line 10: | ||
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID:019911771</ref><ref group="xtra">PMID:017004270</ref><ref group="xtra">PMID:018200648</ref><references group="xtra"/> | + | <ref group="xtra">PMID:019911771</ref><ref group="xtra">PMID:017004270</ref><ref group="xtra">PMID:018200648</ref><references group="xtra"/><references/> |
[[Category: 3-dehydroquinate dehydratase]] | [[Category: 3-dehydroquinate dehydratase]] | ||
[[Category: Helicobacter pylori]] | [[Category: Helicobacter pylori]] | ||
Revision as of 08:10, 8 May 2013
Contents |
STRUCTURE OF HELICOBACTER PYLORI TYPE II DEHYDROQUINASE WITH A NEW CARBASUGAR-THIOPHENE INHIBITOR.
Template:ABSTRACT PUBMED 19911771
Function
[AROQ_HELPY] Catalyzes a trans-dehydration via an enolate intermediate (By similarity).[HAMAP-Rule:MF_00169]
About this Structure
2wks is a 6 chain structure with sequence from Helicobacter pylori. Full crystallographic information is available from OCA.
Reference
- Prazeres VF, Tizon L, Otero JM, Guardado-Calvo P, Llamas-Saiz AL, van Raaij MJ, Castedo L, Lamb H, Hawkins AR, Gonzalez-Bello C. Synthesis and Biological Evaluation of New Nanomolar Competitive Inhibitors of Helicobacter pylori Type II Dehydroquinase. Structural Details of the Role of the Aromatic Moieties with Essential Residues (double dagger). J Med Chem. 2009 Nov 13. PMID:19911771 doi:10.1021/jm9010466
- Gonzalez-Bello C, Castedo L. Progress in type II dehydroquinase inhibitors: from concept to practice. Med Res Rev. 2007 Mar;27(2):177-208. PMID:17004270 doi:10.1002/med.20076
- Sanchez-Sixto C, Prazeres VF, Castedo L, Suh SW, Lamb H, Hawkins AR, Canada FJ, Jimenez-Barbero J, Gonzalez-Bello C. Competitive inhibitors of Helicobacter pylori type II dehydroquinase: synthesis, biological evaluation, and NMR studies. ChemMedChem. 2008 May;3(5):756-70. PMID:18200648 doi:10.1002/cmdc.200700307
