3q90
From Proteopedia
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{{STRUCTURE_3q90| PDB=3q90 | SCENE= }} | {{STRUCTURE_3q90| PDB=3q90 | SCENE= }} | ||
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===Crystal structure of the NTF2 domain of Ras GTPase-activating protein-binding protein 1=== | ===Crystal structure of the NTF2 domain of Ras GTPase-activating protein-binding protein 1=== | ||
| + | ==Function== | ||
| + | [[http://www.uniprot.org/uniprot/G3BP1_HUMAN G3BP1_HUMAN]] May be a regulated effector of stress granule assembly. Phosphorylation-dependent sequence-specific endoribonuclease in vitro. Cleaves exclusively between cytosine and adenine and cleaves MYC mRNA preferentially at the 3'-UTR. ATP- and magnesium-dependent helicase. Unwinds preferentially partial DNA and RNA duplexes having a 17 bp annealed portion and either a hanging 3' tail or hanging tails at both 5'- and 3'-ends. Unwinds DNA/DNA, RNA/DNA, and RNA/RNA substrates with comparable efficiency. Acts unidirectionally by moving in the 5' to 3' direction along the bound single-stranded DNA.<ref>PMID:9889278</ref> <ref>PMID:11604510</ref> | ||
==About this Structure== | ==About this Structure== | ||
[[3q90]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q90 OCA]. | [[3q90]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q90 OCA]. | ||
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| + | ==Reference== | ||
| + | <references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Arrowsmith, C H.]] | [[Category: Arrowsmith, C H.]] | ||
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[[Category: Weigelt, J.]] | [[Category: Weigelt, J.]] | ||
[[Category: Welin, M.]] | [[Category: Welin, M.]] | ||
| + | [[Category: Dna and rna binding]] | ||
| + | [[Category: Hydrolase]] | ||
| + | [[Category: Nucleus]] | ||
| + | [[Category: Plasma membrane]] | ||
| + | [[Category: Protein binding and helicase]] | ||
| + | [[Category: Sgc]] | ||
| + | [[Category: Structural genomic]] | ||
| + | [[Category: Structural genomics consortium]] | ||
Revision as of 08:10, 8 May 2013
Contents |
Crystal structure of the NTF2 domain of Ras GTPase-activating protein-binding protein 1
Function
[G3BP1_HUMAN] May be a regulated effector of stress granule assembly. Phosphorylation-dependent sequence-specific endoribonuclease in vitro. Cleaves exclusively between cytosine and adenine and cleaves MYC mRNA preferentially at the 3'-UTR. ATP- and magnesium-dependent helicase. Unwinds preferentially partial DNA and RNA duplexes having a 17 bp annealed portion and either a hanging 3' tail or hanging tails at both 5'- and 3'-ends. Unwinds DNA/DNA, RNA/DNA, and RNA/RNA substrates with comparable efficiency. Acts unidirectionally by moving in the 5' to 3' direction along the bound single-stranded DNA.[1] [2]
About this Structure
3q90 is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- ↑ Costa M, Ochem A, Staub A, Falaschi A. Human DNA helicase VIII: a DNA and RNA helicase corresponding to the G3BP protein, an element of the ras transduction pathway. Nucleic Acids Res. 1999 Feb 1;27(3):817-21. PMID:9889278
- ↑ Tourriere H, Gallouzi IE, Chebli K, Capony JP, Mouaikel J, van der Geer P, Tazi J. RasGAP-associated endoribonuclease G3Bp: selective RNA degradation and phosphorylation-dependent localization. Mol Cell Biol. 2001 Nov;21(22):7747-60. PMID:11604510 doi:10.1128/MCB.21.22.7747-7760.2001
Categories: Homo sapiens | Arrowsmith, C H. | Berg, S Van Der. | Berglund, H. | Bountra, C. | Collins, R. | Edwards, A M. | Ekblad, T. | Flodin, S. | Flores, A. | Graslund, S. | Hammarstrom, M. | Johansson, I. | Karlberg, T. | Kol, S. | Kotenyova, T. | Kouznetsova, E. | Moche, M. | Nordlund, P. | Nyman, T. | Persson, C. | SGC, Structural Genomics Consortium. | Schuler, H. | Schutz, P. | Siponen, M I. | Thorsell, A G. | Tresaugues, L. | Wahlberg, E. | Weigelt, J. | Welin, M. | Dna and rna binding | Hydrolase | Nucleus | Plasma membrane | Protein binding and helicase | Sgc | Structural genomic | Structural genomics consortium
