3qsv
From Proteopedia
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{{STRUCTURE_3qsv| PDB=3qsv | SCENE= }} | {{STRUCTURE_3qsv| PDB=3qsv | SCENE= }} | ||
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===Structural basis for DNA recognition by constitutive Smad4 MH1 dimers=== | ===Structural basis for DNA recognition by constitutive Smad4 MH1 dimers=== | ||
| + | {{ABSTRACT_PUBMED_021724602}} | ||
| + | ==Function== | ||
| + | [[http://www.uniprot.org/uniprot/SMAD4_MOUSE SMAD4_MOUSE]] Common SMAD (co-SMAD) is the coactivator and mediator of signal transduction by TGF-beta (transforming growth factor). Component of the heterotrimeric SMAD2/SMAD3-SMAD4 complex that forms in the nucleus and is required for the TGF-mediated signaling. Promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription. Component of the multimeric SMAD3/SMAD4/JUN/FOS complex which forms at the AP1 promoter site; required for syngernistic transcriptional activity in response to TGF-beta. May act as a tumor suppressor. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator (By similarity). | ||
==About this Structure== | ==About this Structure== | ||
Revision as of 08:12, 8 May 2013
Structural basis for DNA recognition by constitutive Smad4 MH1 dimers
Template:ABSTRACT PUBMED 021724602
Function
[SMAD4_MOUSE] Common SMAD (co-SMAD) is the coactivator and mediator of signal transduction by TGF-beta (transforming growth factor). Component of the heterotrimeric SMAD2/SMAD3-SMAD4 complex that forms in the nucleus and is required for the TGF-mediated signaling. Promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription. Component of the multimeric SMAD3/SMAD4/JUN/FOS complex which forms at the AP1 promoter site; required for syngernistic transcriptional activity in response to TGF-beta. May act as a tumor suppressor. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator (By similarity).
About this Structure
3qsv is a 8 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA.
