3pyc
From Proteopedia
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{{STRUCTURE_3pyc| PDB=3pyc | SCENE= }} | {{STRUCTURE_3pyc| PDB=3pyc | SCENE= }} | ||
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===Crystal structure of human SMURF1 C2 domain=== | ===Crystal structure of human SMURF1 C2 domain=== | ||
| + | {{ABSTRACT_PUBMED_021402695}} | ||
| + | ==Function== | ||
| + | [[http://www.uniprot.org/uniprot/SMUF1_HUMAN SMUF1_HUMAN]] E3 ubiquitin-protein ligase that acts as a negative regulator of BMP signaling pathway. Mediates ubiquitination and degradation of SMAD1 and SMAD5, 2 receptor-regulated SMADs specific for the BMP pathway. Promotes ubiquitination and subsequent proteasomal degradation of TRAF family members and RHOA.<ref>PMID:10458166</ref> <ref>PMID:19937093</ref> <ref>PMID:21402695</ref> | ||
==About this Structure== | ==About this Structure== | ||
[[3pyc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PYC OCA]. | [[3pyc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PYC OCA]. | ||
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| + | ==See Also== | ||
| + | *[[Ubiquitin protein ligase|Ubiquitin protein ligase]] | ||
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| + | ==Reference== | ||
| + | <ref group="xtra">PMID:021402695</ref><references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Li, P.]] | [[Category: Li, P.]] | ||
[[Category: Li, X.]] | [[Category: Li, X.]] | ||
| + | [[Category: Lipid binding protein]] | ||
| + | [[Category: Membrane associate]] | ||
| + | [[Category: Phospholipid binding]] | ||
Revision as of 08:15, 8 May 2013
Contents |
Crystal structure of human SMURF1 C2 domain
Template:ABSTRACT PUBMED 021402695
Function
[SMUF1_HUMAN] E3 ubiquitin-protein ligase that acts as a negative regulator of BMP signaling pathway. Mediates ubiquitination and degradation of SMAD1 and SMAD5, 2 receptor-regulated SMADs specific for the BMP pathway. Promotes ubiquitination and subsequent proteasomal degradation of TRAF family members and RHOA.[1] [2] [3]
About this Structure
3pyc is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
See Also
Reference
- Lu K, Li P, Zhang M, Xing G, Li X, Zhou W, Bartlam M, Zhang L, Rao Z, He F. Pivotal role of the C2 domain of the Smurf1 ubiquitin ligase in substrate selection. J Biol Chem. 2011 May 13;286(19):16861-70. Epub 2011 Mar 14. PMID:21402695 doi:10.1074/jbc.M110.211979
- ↑ Zhu H, Kavsak P, Abdollah S, Wrana JL, Thomsen GH. A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation. Nature. 1999 Aug 12;400(6745):687-93. PMID:10458166 doi:10.1038/23293
- ↑ Li S, Lu K, Wang J, An L, Yang G, Chen H, Cui Y, Yin X, Xie P, Xing G, He F, Zhang L. Ubiquitin ligase Smurf1 targets TRAF family proteins for ubiquitination and degradation. Mol Cell Biochem. 2010 May;338(1-2):11-7. doi: 10.1007/s11010-009-0315-y. Epub, 2009 Nov 24. PMID:19937093 doi:10.1007/s11010-009-0315-y
- ↑ Lu K, Li P, Zhang M, Xing G, Li X, Zhou W, Bartlam M, Zhang L, Rao Z, He F. Pivotal role of the C2 domain of the Smurf1 ubiquitin ligase in substrate selection. J Biol Chem. 2011 May 13;286(19):16861-70. Epub 2011 Mar 14. PMID:21402695 doi:10.1074/jbc.M110.211979
