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3pr2

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[[Image:3pr2.jpg|left|200px]]
 
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{{STRUCTURE_3pr2| PDB=3pr2 | SCENE= }}
{{STRUCTURE_3pr2| PDB=3pr2 | SCENE= }}
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===Tryptophan synthase indoline quinonoid structure with F9 inhibitor in alpha site===
===Tryptophan synthase indoline quinonoid structure with F9 inhibitor in alpha site===
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{{ABSTRACT_PUBMED_21142052}}
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==Function==
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[[http://www.uniprot.org/uniprot/TRPA_SALTY TRPA_SALTY]] The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. [[http://www.uniprot.org/uniprot/TRPB_SALTY TRPB_SALTY]] The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.
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{{ABSTRACT_PUBMED_21142052}}
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==About this Structure==
==About this Structure==
[[3pr2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_typhimurium Salmonella enterica subsp. enterica serovar typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PR2 OCA].
[[3pr2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_typhimurium Salmonella enterica subsp. enterica serovar typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PR2 OCA].
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==See Also==
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*[[Tryptophan synthase|Tryptophan synthase]]
==Reference==
==Reference==
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<ref group="xtra">PMID:21142052</ref><references group="xtra"/>
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<ref group="xtra">PMID:021142052</ref><references group="xtra"/><references/>
[[Category: Salmonella enterica subsp. enterica serovar typhimurium]]
[[Category: Salmonella enterica subsp. enterica serovar typhimurium]]
[[Category: Tryptophan synthase]]
[[Category: Tryptophan synthase]]
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[[Category: Schwarz, F.]]
[[Category: Schwarz, F.]]
[[Category: Wang, Y.]]
[[Category: Wang, Y.]]
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[[Category: Alpha-beta barrel]]
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[[Category: Lyase]]
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[[Category: Tim-barrel]]
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[[Category: Tryptophan synthesis]]

Revision as of 08:22, 8 May 2013

Template:STRUCTURE 3pr2

Contents

Tryptophan synthase indoline quinonoid structure with F9 inhibitor in alpha site

Template:ABSTRACT PUBMED 21142052

Function

[TRPA_SALTY] The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. [TRPB_SALTY] The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

About this Structure

3pr2 is a 2 chain structure with sequence from Salmonella enterica subsp. enterica serovar typhimurium. Full crystallographic information is available from OCA.

See Also

Reference

  • Lai J, Niks D, Wang Y, Domratcheva T, Barends TR, Schwarz F, Olsen RA, Elliott DW, Fatmi MQ, Chang CE, Schlichting I, Dunn MF, Mueller LJ. X-ray and NMR crystallography in an enzyme active site: the indoline quinonoid intermediate in tryptophan synthase. J Am Chem Soc. 2011 Jan 12;133(1):4-7. Epub 2010 Dec 10. PMID:21142052 doi:10.1021/ja106555c

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