3qj9
From Proteopedia
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{{STRUCTURE_3qj9| PDB=3qj9 | SCENE= }} | {{STRUCTURE_3qj9| PDB=3qj9 | SCENE= }} | ||
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===Crystal structure of fatty acid amide hydrolase with small molecule inhibitor=== | ===Crystal structure of fatty acid amide hydrolase with small molecule inhibitor=== | ||
| + | {{ABSTRACT_PUBMED_21502526}} | ||
| - | + | ==Function== | |
| - | + | [[http://www.uniprot.org/uniprot/FAAH1_RAT FAAH1_RAT]] Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates (By similarity). | |
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==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID:021502526</ref><references group="xtra"/> | + | <ref group="xtra">PMID:021502526</ref><references group="xtra"/><references/> |
[[Category: Fatty acid amide hydrolase]] | [[Category: Fatty acid amide hydrolase]] | ||
[[Category: Rattus norvegicus]] | [[Category: Rattus norvegicus]] | ||
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[[Category: Walker, N P.C.]] | [[Category: Walker, N P.C.]] | ||
[[Category: Wang, Z.]] | [[Category: Wang, Z.]] | ||
| + | [[Category: Faah]] | ||
| + | [[Category: Fatty-acid amide hydrolase]] | ||
| + | [[Category: Hydrolase-hydrolase inhibitor complex]] | ||
| + | [[Category: Protein-inhibitor complex]] | ||
Revision as of 08:30, 8 May 2013
Contents |
Crystal structure of fatty acid amide hydrolase with small molecule inhibitor
Template:ABSTRACT PUBMED 21502526
Function
[FAAH1_RAT] Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates (By similarity).
About this Structure
3qj9 is a 2 chain structure with sequence from Rattus norvegicus. Full crystallographic information is available from OCA.
Reference
- Min X, Thibault ST, Porter AC, Gustin DJ, Carlson TJ, Xu H, Lindstrom M, Xu G, Uyeda C, Ma Z, Li Y, Kayser F, Walker NP, Wang Z. Discovery and molecular basis of potent noncovalent inhibitors of fatty acid amide hydrolase (FAAH). Proc Natl Acad Sci U S A. 2011 May 3;108(18):7379-84. Epub 2011 Apr 18. PMID:21502526 doi:10.1073/pnas.1016167108
