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3pwq

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[[Image:3pwq.png|left|200px]]
 
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{{STRUCTURE_3pwq| PDB=3pwq | SCENE= }}
{{STRUCTURE_3pwq| PDB=3pwq | SCENE= }}
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===The Phenylacetyl-CoA monooxygenase PaaAC subcomplex===
===The Phenylacetyl-CoA monooxygenase PaaAC subcomplex===
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{{ABSTRACT_PUBMED_21247899}}
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==Function==
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[[http://www.uniprot.org/uniprot/PAAC_ECOLI PAAC_ECOLI]] Component of 1,2-phenylacetyl-CoA epoxidase multicomponent enzyme system which catalyzes the reduction of phenylacetyl-CoA (PA-CoA) to form 1,2-epoxyphenylacetyl-CoA. The subunit C may be essential for structural integrity of the alpha subunit.<ref>PMID:9748275</ref> <ref>PMID:16997993</ref> <ref>PMID:20660314</ref> [[http://www.uniprot.org/uniprot/PAAA_ECOLI PAAA_ECOLI]] Component of 1,2-phenylacetyl-CoA epoxidase multicomponent enzyme system which catalyzes the reduction of phenylacetyl-CoA (PA-CoA) to form 1,2-epoxyphenylacetyl-CoA. The subunit A is the catalytic subunit involved in the incorporation of one atom of molecular oxygen into phenylacetyl-CoA.<ref>PMID:9748275</ref> <ref>PMID:16997993</ref> <ref>PMID:20660314</ref> <ref>PMID:21247899</ref>
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{{ABSTRACT_PUBMED_21247899}}
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==About this Structure==
==About this Structure==
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==Reference==
==Reference==
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<ref group="xtra">PMID:21247899</ref><references group="xtra"/>
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<ref group="xtra">PMID:021247899</ref><references group="xtra"/><references/>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: BSGI, Montreal-Kingston Bacterial Structural Genomics Initiative.]]
[[Category: BSGI, Montreal-Kingston Bacterial Structural Genomics Initiative.]]
[[Category: Cygler, M.]]
[[Category: Cygler, M.]]
[[Category: Grishin, A M.]]
[[Category: Grishin, A M.]]
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[[Category: Bacterial multicomponent monooxygenase]]
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[[Category: Bsgi]]
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[[Category: Ferritin-like fold]]
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[[Category: Montreal-kingston bacterial structural genomics initiative]]
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[[Category: Oxidoreductase]]
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[[Category: Protein-protein complex]]
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[[Category: Structural genomic]]

Revision as of 08:30, 8 May 2013

Template:STRUCTURE 3pwq

Contents

The Phenylacetyl-CoA monooxygenase PaaAC subcomplex

Template:ABSTRACT PUBMED 21247899

Function

[PAAC_ECOLI] Component of 1,2-phenylacetyl-CoA epoxidase multicomponent enzyme system which catalyzes the reduction of phenylacetyl-CoA (PA-CoA) to form 1,2-epoxyphenylacetyl-CoA. The subunit C may be essential for structural integrity of the alpha subunit.[1] [2] [3] [PAAA_ECOLI] Component of 1,2-phenylacetyl-CoA epoxidase multicomponent enzyme system which catalyzes the reduction of phenylacetyl-CoA (PA-CoA) to form 1,2-epoxyphenylacetyl-CoA. The subunit A is the catalytic subunit involved in the incorporation of one atom of molecular oxygen into phenylacetyl-CoA.[4] [5] [6] [7]

About this Structure

3pwq is a 12 chain structure with sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

  • Grishin AM, Ajamian E, Tao L, Zhang L, Menard R, Cygler M. Structural and functional studies of the Escherichia coli phenylacetyl-coa monooxygenase complex. J Biol Chem. 2011 Jan 19. PMID:21247899 doi:10.1074/jbc.M110.194423
  1. ↑ Ferrandez A, Minambres B, Garcia B, Olivera ER, Luengo JM, Garcia JL, Diaz E. Catabolism of phenylacetic acid in Escherichia coli. Characterization of a new aerobic hybrid pathway. J Biol Chem. 1998 Oct 2;273(40):25974-86. PMID:9748275
  2. ↑ Fernandez C, Ferrandez A, Minambres B, Diaz E, Garcia JL. Genetic characterization of the phenylacetyl-coenzyme A oxygenase from the aerobic phenylacetic acid degradation pathway of Escherichia coli. Appl Environ Microbiol. 2006 Nov;72(11):7422-6. Epub 2006 Sep 22. PMID:16997993 doi:10.1128/AEM.01550-06
  3. ↑ Teufel R, Mascaraque V, Ismail W, Voss M, Perera J, Eisenreich W, Haehnel W, Fuchs G. Bacterial phenylalanine and phenylacetate catabolic pathway revealed. Proc Natl Acad Sci U S A. 2010 Aug 10;107(32):14390-5. doi:, 10.1073/pnas.1005399107. Epub 2010 Jul 21. PMID:20660314 doi:10.1073/pnas.1005399107
  4. ↑ Ferrandez A, Minambres B, Garcia B, Olivera ER, Luengo JM, Garcia JL, Diaz E. Catabolism of phenylacetic acid in Escherichia coli. Characterization of a new aerobic hybrid pathway. J Biol Chem. 1998 Oct 2;273(40):25974-86. PMID:9748275
  5. ↑ Fernandez C, Ferrandez A, Minambres B, Diaz E, Garcia JL. Genetic characterization of the phenylacetyl-coenzyme A oxygenase from the aerobic phenylacetic acid degradation pathway of Escherichia coli. Appl Environ Microbiol. 2006 Nov;72(11):7422-6. Epub 2006 Sep 22. PMID:16997993 doi:10.1128/AEM.01550-06
  6. ↑ Teufel R, Mascaraque V, Ismail W, Voss M, Perera J, Eisenreich W, Haehnel W, Fuchs G. Bacterial phenylalanine and phenylacetate catabolic pathway revealed. Proc Natl Acad Sci U S A. 2010 Aug 10;107(32):14390-5. doi:, 10.1073/pnas.1005399107. Epub 2010 Jul 21. PMID:20660314 doi:10.1073/pnas.1005399107
  7. ↑ Grishin AM, Ajamian E, Tao L, Zhang L, Menard R, Cygler M. Structural and functional studies of the Escherichia coli phenylacetyl-coa monooxygenase complex. J Biol Chem. 2011 Jan 19. PMID:21247899 doi:10.1074/jbc.M110.194423

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