3pz2
From Proteopedia
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| - | [[Image:3pz2.png|left|200px]] | ||
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{{STRUCTURE_3pz2| PDB=3pz2 | SCENE= }} | {{STRUCTURE_3pz2| PDB=3pz2 | SCENE= }} | ||
| + | ===Crystal structure of RabGGTase(DELTA LRR; DELTA IG) in Complex with BMS3 and lipid substrate GGPP=== | ||
| - | === | + | ==Disease== |
| + | [[http://www.uniprot.org/uniprot/PGTA_MOUSE PGTA_MOUSE]] Note=Defects in Rabggta are the cause of the gunmetal (gm) phenotype. Mice homozygous for gm have prolonged bleeding, thrombocytopenia and reduced platelet alpha- and delta-granule contents. | ||
| + | ==Function== | ||
| + | [[http://www.uniprot.org/uniprot/PGTA_MOUSE PGTA_MOUSE]] Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to both cysteines in Rab proteins with an -XXCC, -XCXC and -CCXX C-terminal, such as RAB1A, RAB3A and RAB5A respectively (By similarity). | ||
==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID:021520375</ref><references group="xtra"/> | + | <ref group="xtra">PMID:021520375</ref><references group="xtra"/><references/> |
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Protein geranylgeranyltransferase type II]] | [[Category: Protein geranylgeranyltransferase type II]] | ||
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[[Category: Stigter, E A.]] | [[Category: Stigter, E A.]] | ||
[[Category: Waldmann, H.]] | [[Category: Waldmann, H.]] | ||
| + | [[Category: Chimera protein]] | ||
| + | [[Category: Fusion protein]] | ||
| + | [[Category: Protein prenylation]] | ||
| + | [[Category: Transferase-transferase inhibitor complex]] | ||
Revision as of 08:35, 8 May 2013
Contents |
Crystal structure of RabGGTase(DELTA LRR; DELTA IG) in Complex with BMS3 and lipid substrate GGPP
Disease
[PGTA_MOUSE] Note=Defects in Rabggta are the cause of the gunmetal (gm) phenotype. Mice homozygous for gm have prolonged bleeding, thrombocytopenia and reduced platelet alpha- and delta-granule contents.
Function
[PGTA_MOUSE] Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to both cysteines in Rab proteins with an -XXCC, -XCXC and -CCXX C-terminal, such as RAB1A, RAB3A and RAB5A respectively (By similarity).
About this Structure
3pz2 is a 2 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA.
Reference
- Bon RS, Guo Z, Stigter EA, Wetzel S, Menninger S, Wolf A, Choidas A, Alexandrov K, Blankenfeldt W, Goody RS, Waldmann H. Structure-Guided Development of Selective RabGGTase Inhibitors. Angew Chem Int Ed Engl. 2011 May 16;50(21):4957-61. doi:, 10.1002/anie.201101210. Epub 2011 Apr 21. PMID:21520375 doi:10.1002/anie.201101210
