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3qf7
From Proteopedia
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{{STRUCTURE_3qf7| PDB=3qf7 | SCENE= }} | {{STRUCTURE_3qf7| PDB=3qf7 | SCENE= }} | ||
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===The Mre11:Rad50 complex forms an ATP dependent molecular clamp in DNA double-strand break repair=== | ===The Mre11:Rad50 complex forms an ATP dependent molecular clamp in DNA double-strand break repair=== | ||
| + | {{ABSTRACT_PUBMED_21458667}} | ||
| - | + | ==Function== | |
| - | + | [[http://www.uniprot.org/uniprot/RAD50_THEMA RAD50_THEMA]] Involved in DNA double-strand break repair (DSBR). The Rad50/Mre11 complex possesses single-strand endonuclease activity and ATP-dependent double-strand-specific 3'-5' exonuclease activity. Rad50 provides an ATP-dependent control of Mre11 by unwinding and/or repositioning DNA ends into the Mre11 active site (By similarity). | |
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==About this Structure== | ==About this Structure== | ||
[[3qf7]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QF7 OCA]. | [[3qf7]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QF7 OCA]. | ||
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| + | ==See Also== | ||
| + | *[[ATPase|ATPase]] | ||
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID: | + | <ref group="xtra">PMID:021458667</ref><references group="xtra"/><references/> |
[[Category: Thermotoga maritima]] | [[Category: Thermotoga maritima]] | ||
[[Category: Lammens, K.]] | [[Category: Lammens, K.]] | ||
[[Category: Moeckel, C.]] | [[Category: Moeckel, C.]] | ||
| + | [[Category: Abc-atpase]] | ||
| + | [[Category: Atpase]] | ||
| + | [[Category: Hydrolase]] | ||
| + | [[Category: Mre11]] | ||
Revision as of 08:36, 8 May 2013
Contents |
The Mre11:Rad50 complex forms an ATP dependent molecular clamp in DNA double-strand break repair
Template:ABSTRACT PUBMED 21458667
Function
[RAD50_THEMA] Involved in DNA double-strand break repair (DSBR). The Rad50/Mre11 complex possesses single-strand endonuclease activity and ATP-dependent double-strand-specific 3'-5' exonuclease activity. Rad50 provides an ATP-dependent control of Mre11 by unwinding and/or repositioning DNA ends into the Mre11 active site (By similarity).
About this Structure
3qf7 is a 4 chain structure with sequence from Thermotoga maritima. Full crystallographic information is available from OCA.
See Also
Reference
- Lammens K, Bemeleit DJ, Mockel C, Clausing E, Schele A, Hartung S, Schiller CB, Lucas M, Angermuller C, Soding J, Strasser K, Hopfner KP. The Mre11:Rad50 Structure Shows an ATP-Dependent Molecular Clamp in DNA Double-Strand Break Repair. Cell. 2011 Apr 1;145(1):54-66. PMID:21458667 doi:10.1016/j.cell.2011.02.038
