3pva

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Revision as of 08:36, 8 May 2013

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Template:STRUCTURE 3pva

Contents 1 PENICILLIN V ACYLASE FROM B. SPHAERICUS 2 Function 3 About this Structure 4 See Also 5 Reference

PENICILLIN V ACYLASE FROM B. SPHAERICUS

Function

[PAC_BACSH] The enzyme catalyzes the conversion of penicillin to 6-aminopenicillanate The precursor, furthermore, acts as a self-processing peptidase that cleaves off the propeptide. All peptidase activity is lost on conversion to the mature peptidase.

About this Structure

3pva is a 8 chain structure with sequence from Lysinibacillus sphaericus. Full crystallographic information is available from OCA.

See Also

• Penicillin acylase

Reference

• Suresh CG, Pundle AV, SivaRaman H, Rao KN, Brannigan JA, McVey CE, Verma CS, Dauter Z, Dodson EJ, Dodson GG. Penicillin V acylase crystal structure reveals new Ntn-hydrolase family members. Nat Struct Biol. 1999 May;6(5):414-6. PMID:10331865 doi:10.1038/8213