2gh0
From Proteopedia
(New page: 200px<br /> <applet load="2gh0" size="450" color="white" frame="true" align="right" spinBox="true" caption="2gh0, resolution 1.92Å" /> '''Growth factor/recep...) |
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| - | [[Image:2gh0.gif|left|200px]]<br /> | + | [[Image:2gh0.gif|left|200px]]<br /><applet load="2gh0" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="2gh0" size=" | + | |
caption="2gh0, resolution 1.92Å" /> | caption="2gh0, resolution 1.92Å" /> | ||
'''Growth factor/receptor complex'''<br /> | '''Growth factor/receptor complex'''<br /> | ||
==Overview== | ==Overview== | ||
| - | Artemin (ARTN) is a member of the glial cell line-derived neurotrophic | + | Artemin (ARTN) is a member of the glial cell line-derived neurotrophic factor (GDNF) family ligands (GFLs) which regulate the development and maintenance of many neuronal populations in the mammalian nervous system. Here we report the 1.92 A crystal structure of the complex formed between ARTN and its receptor GFRalpha3, which is the initiating step in the formation of a ternary signaling complex containing the shared RET receptor. It represents a new receptor-ligand interaction mode for the TGF-beta superfamily that reveals both conserved and specificity-determining anchor points for all GFL-GFRalpha pairs. In tandem with the complex structure, cellular studies using receptor chimeras implicate dyad-symmetric composite interfaces for recruitment and dimerization of RET, leading to intracellular signaling. These studies should facilitate the functional dissection of the specific versus pleiotropic roles of this system in neurobiology, as well as its exploitation for therapeutic applications. |
==About this Structure== | ==About this Structure== | ||
| - | 2GH0 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with NAG as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | + | 2GH0 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=NAG:'>NAG</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GH0 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
| - | [[Category: Wang, X | + | [[Category: Wang, X Q.]] |
[[Category: NAG]] | [[Category: NAG]] | ||
[[Category: cystine-knot]] | [[Category: cystine-knot]] | ||
[[Category: helix bundle]] | [[Category: helix bundle]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:31:35 2008'' |
Revision as of 15:31, 21 February 2008
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Growth factor/receptor complex
Overview
Artemin (ARTN) is a member of the glial cell line-derived neurotrophic factor (GDNF) family ligands (GFLs) which regulate the development and maintenance of many neuronal populations in the mammalian nervous system. Here we report the 1.92 A crystal structure of the complex formed between ARTN and its receptor GFRalpha3, which is the initiating step in the formation of a ternary signaling complex containing the shared RET receptor. It represents a new receptor-ligand interaction mode for the TGF-beta superfamily that reveals both conserved and specificity-determining anchor points for all GFL-GFRalpha pairs. In tandem with the complex structure, cellular studies using receptor chimeras implicate dyad-symmetric composite interfaces for recruitment and dimerization of RET, leading to intracellular signaling. These studies should facilitate the functional dissection of the specific versus pleiotropic roles of this system in neurobiology, as well as its exploitation for therapeutic applications.
About this Structure
2GH0 is a Protein complex structure of sequences from Homo sapiens with as ligand. Full crystallographic information is available from OCA.
Reference
Structure of artemin complexed with its receptor GFRalpha3: convergent recognition of glial cell line-derived neurotrophic factors., Wang X, Baloh RH, Milbrandt J, Garcia KC, Structure. 2006 Jun;14(6):1083-92. PMID:16765900
Page seeded by OCA on Thu Feb 21 17:31:35 2008
