Tyrosine phosphatase

From Proteopedia

Revision as of 11:58, 12 May 2013

Template:STRUCTURE 3i7z

Tyrosine phosphatase (PTP) is an enzyme which removes phosphate from phosphorylated tyrosine residues. It is a key regulatory component of signal transduction pathways. PTPs are divided to 4 subfamilies. PTP class I contains receptor PTPs (RPTP) and dual-specificity PTP which removes phosphate from Ser/Thr and tyrosine. PTP class III contains CDC25 which removes phosphate from Thr and tyrosine. PTP containing SH2 domains are called PTP SHP. For details on Yersinia PTP see Yersinia YopH.

3D Structures of tyrosine phosphatase

Updated on 12-May-2013

Class I

Non-receptor type PTP

1a5y, 2hnp, 2hnq, 1oem, 1oeo, 1oes, 1oet, 1oeu, 1oev, 1sug, 2cm2, 2cm3, 3eu0, 3i80, 3a5j, 1bzc - hPTP-b catalytic domain – human
1gfy, 1i57, 1pa1, 2f6f, 3a5k, 3zv2, 3qkp, 3qkq - hPTP-b catalytic domain (mutant)
1wch – hPTP-e
3pdz - hPTP-e PDZ2 domain – NMR
1gm1 - mPTP-BL PDZ2 domain – mouse – NMR
1ozi - mPTP-BL PDZ2 domain (mutant) – NMR
3rgo – mPTP-1
2yz1 – mPTP SHPS-1 catalytic domain
1gwz, 2b3o – hPTP SHP-1 catalytic domain
1x6c - hPTP SHP-1 SH2 domain – NMR
2shp - hPTP SHP-2 (mutant)
2b49 – hPTPN3 catalytic domain 2i75 – hPTPN4
2cs5 – hPTPN4 PDZ domain – NMR
2vph - hPTPN4 PDZ domain
2bij – hPTPN5 catalytic domain
2bv5 - hPTPN5 catalytic domain (mutant)
3ps5 – hPTPN6 (mutant)
2a3k, 1zc0 – hPTPN7 catalytic domain
2gp0, 2hvl, 2qdc, 2qdm, 2qdp, 2qds, 2qdt, 2qdu – hPTPN7 catalytic domain (mutant)
2pa5 – hPTPN9 catalytic domain 3b7o - hPTPN11 catalytic domain
3lnx – hPTPN13 PDZ2 domain
2bzl – hPTPN14 catalytic domain 2oc3 – hPTPN18 2p6x, 2qcj, 3h2x – hPTPN22 catalytic domain
3rau - hPTPN23 His domain 1xm2 – hPTP PRL-1
1r6h, 1v3a – hPTP IVA-3 – NMR
1rxd - hPTP IVA-1
1zck, 1x24 – rPTP 4A1 – rat
3i36 – rPTP-η catalytic domain
1yts - YePTP catalytic domain (mutant) – Yersinia enterocolitica
1huf, 1k46 - YePTP N terminal domain
1c0e – bPTP (mutant) – bovine
1d1p – yPTP - yeast
1g4w – StPTP – Salmonella typhimurium
2i6i, 3ro1 – SsPTP – Sulfolobus solfataricus
2pi7 – cPTP CRYP-2 catalytic domain
2z72, 1v73, 2zbm – PTP residues 22-361 – Shewanella
3js5, 3jvi – EhPTP – Entamoeba histolytica
2wjd, 2wje, 2wjf – PTP – Streptococcus pneumonia
3qy6, 3qy7, 3qy8 – PTP – Bacillus subtilis

Non-receptor type PTP complex with peptide

1ptt, 1ptu, 1g1f, 1g1g, 1g1h, 1een, 1eeo - hPTP-b catalytic domain (mutant) + peptide
3i7z - hPTP-b catalytic domain + peptide
3nfk, 3nfl - hPTPN4 PDZ domain + peptide
2yu7, 2rmx – hPTPN6 SH2 domain + peptide – NMR
3d42, 3d44 – hPTPN7 catalytic domain (mutant) + peptide
3tl0, 3tkz – hPTPN11 SH2 domain + peptide
3lny - hPTPN13 PDZ2 domain + peptide
3brh, 3olr - hPTPN22 catalytic domain + peptide
3omh - hPTPN22 catalytic domain (mutant) + peptide
3rz2 - rPTP 4A1 + peptide
1fpr - hPTP SHP-1 catalytic domain + peptide
1qz0, 1xxp, 1xxv - YePTP catalytic domain (mutant) + peptide
1m0v - YePTP N terminal domain + peptide - NMR
1aya, 1ayb, 1ayc, 1ayd – mPTP Syp N terminal SH2 domain + peptide
2dxp, 2i6o – SsPTP (mutant) + peptide

Non-receptor type PTP complex with small molecule

1ptv, 1pty - hPTP-b catalytic domain (mutant) + phosphotyrosine
1aax - hPTP-b catalytic domain (mutant) + bis-phosphophenyl methane
1ecv, 1c83, 1c84, 1c85, 1c86, 1c87, 1c88, 1g7f, 1g7g, 1jf7, 1l8g, 1kak, 1kav, 1lqf, 1nl9, 1nny, 1no6, 1nz7, 1ony, 1onz, 1ph0, 1pxh, 1pyn, 1q1m, 1q6j, 1q6m, 1q6n, 1q6p, 1q6s, 1q6t, 1qxk, 1t48, 1t49, 1t4j, 1xbo, 1wax, 2bgd, 2bge, 2azr, 2b07, 2f6t, 2f6v, 2f6w, 2f6y, 2f6z, 2f70, 2f71, 2fjn, 2cm7, 2cm8, 2cma, 2cmb, 2cmc, 2h4g, 2h4k, 2hb1, 2cne, 2cnf, 2cng, 2cnh, 2cni, 2nt7, 2nta, 2veu, 2vev, 2vew, 2vex, 2vey, 2qbp, 2qbq, 2qbr, 2qbs, 3cwe, 3d9c, 2zmm, 2zn7, 3eax, 3eb1, 3sme, 4i8n - hPTP-b catalytic domain + inhibitor
1nwl, 1nwe, 2fjm - hPTP-b catalytic domain (mutant) + inhibitor
3rgq – mPTP-1 + Pi(5)P
2cjz - hPTPN5 catalytic domain (mutant) + phosphotyrosine 3o5x – hPTPN11 catalytic domain + inhibitor
3mow - hPTPN11 catalytic domain + tautomycetin analog 2qct – hPTPN22 catalytic domain + inhibitor
1zcl - rPTP 4A1 (mutant) + sulfate
2y2f - YePTP catalytic domain + inhibitor
2i42 – YePTP (mutant) + VO4
1ypt, 1ytw – YePTP catalytic domain + WO4
1ytn - YePTP catalytic domain + NO3
1lyv - YePTP catalytic domain (mutant) + phosphate
1pa9 - YePTP catalytic domain (mutant) + inhibitor
1dg9 – bPTP + HEPES
1d2a – yPTP + adenine
1d1q – yPTP (mutant) + PNPP
2i6p - SsPTP (mutant) + PNPP
2i6j – SsPTP + phosphate
2i6m – SsPTP + WO4
3ido – EhPTP + HEPES

PTP binary complex with polypeptide

1aya, 1ayb, 1ayc, 1ayd – mPTP Syp SH2 domain + peptide
1lqf - hPTP 1B catalytic domain + phosphopeptide
1ptt, 1ptu, 1een, 1eeo, 1nwl - hPTP 1B catalytic domain (mutant) + phosphopeptide
1ptv, 1pty - hPTP 1B catalytic domain (mutant) + phosphotyrosine
3i7z, 3i80 - hPTP 1B catalytic domain + peptide
1g1f, 1g1g, 1g1h - hPTP 1B catalytic domain (mutant) + peptide
1bzh - hPTP 1B catalytic domain + fluoromalonyl tyrosine peptide
1bzj - hPTP 1B catalytic domain + phosphotyrosine mimetic
3nfk, 3nfl - hPTP N4 PDZ domain + peptide
2cjz - hPTP N5 catalytic domain (mutant) + phosphotyrosine
1fpr - hPTP N6 catalytic domain (mutant) + peptide
2yu7, 2rmx - hPTP N6 SH2 domain + phosphopeptide – NMR
3d42, 3d44 - hPTP N7 catalytic domain (mutant) + phosphopeptide
3tl0, 3tkz - hPTP N11 SH2 domain + peptide
3lny - hPTP N13 PDZ domain + peptide
3brh, 3olr, 3omh - hPTP N22 catalytic domain (mutant) + phosphopeptide
1ygr – hPTP CD45 (mutant) + peptide
2dxp, 2i6o - SsPTP (mutant) + phosphopeptide
3rz2 – rPRP PRL-1 + peptide
3s3h – DmPTP 10D catalytic domain + phosphopeptide

Non-receptor type PTP complex with protein

2b4s - hPTP-b catalytic domain + insulin receptor
2gph - hPTPN7 catalytic domain (mutant) + MAPK2
1g4u – StPTP + RAS-related C3 botulinum toxin substrate
1jyo – StPTP + secretion chaperone SICP

Receptor-type PTP

1yfo – mRPTP-α catalytic domain
1p15 - mRPTP-α D2 domain
3pxh - mRPTP Ig domains
2nv5 – RPRP - rat 2ahs – hRPTP-β
2i3r, 2i5x - hRPTP-β catalytic domain
2hc1, 2hc2 - hRPTP-β catalytic domain (mutant)
2h4v, 2pbn – hRPTP-γ residues 831-1127
2nlk - hRPTP-γ catalytic domain
3jxg - mRPTP-γ CA-like domain
3jxh - hRPTP-γ CA-like domain 1x5z - hRPTP-δ fibronectin type-III domain – NMR
2dlh - hRPTP-δ FN3 domain – NMR
2yd6, 2yd7 - hRPTP-δ Ig1-2 domain 2jjd - hRPTP-ε residues 107-697 2c7s - hRPTP-κ residues 865-1154 1rpm - hRPTP-μ catalytic domain
2c9a - hRPTP-μ MAM-IG module
2v5y - hRPTP-μ extracellular region 2g59, 2gjt - hRPTP-ο catalytic domain 2cfv – hRPTP-η residues 1019-1311
2nz6 - hRPTP-η residues 1019-1311 (mutant)
2dle - hRPTP-η FN3 domain – NMR
2fh7 - hRPTP-σ catalytic domain (mutant)
2yd9 - hRPTP-σ Ig1-3 domain (mutant)
2yd3, 2yd5 - hRPTP-σ Ig1-2 domain
2yd4 - cRPTP-σ Ig1-2 domain – chicken 3jxf - hRPTP-ζ CA-like domain
2qt7, 3n01, 3n4w, 3ng8, 3np5 – hRPTP IA-2 1jln, 2a8b - mRPTP-R catalytic domain
2edx - hRPTP-F fibronectin type-III domain – NMR
2yd1, 2yd2 – DmRPTP Ig1-2 domain – Drosophila melanogaster
3s3e – DmRPTP-10D catalytic domain

Receptor type PTP complexes

3s3f - DmRPTP-10D catalytic domain + VO4
3s3h - DmRPTP-10D catalytic domain + peptide
3s3k - DmRPTP-10D catalytic domain + inhibitor
2h02, 2h04, 2i3u, 2i4e, 2i4g, 2i4h - hRPTP-β catalytic domain + inhibitor
2h03 - hRPTP-β catalytic domain (mutant) + inhibitor
2hy3 - hRPTP-γ residues 819-1130 + VO4
3kld - mRPTP-γ CA-like domain + contactin 4
2yd8 - hRPTP-σ Ig1-2 domain + sucrose octasulfate
3s97 - hRPTP-ζ CA-like domain + congtactin Ig domains
1ygr – hRPTP CD45 cytoplasmic domain (mutant) + T-cell receptor peptide

Dual-specificity PTP

1t3k – PTP (mutant) – Arabidopsis thaliana
2wgp – hPTP-14 residues 2-191

Class II – Low molecular weight PTP

1p8a – PTP (mutant) – Tritrichomonas foetus – NMR
2cwd – PTP – Thermus thermophilus
1phr - bPTP
1xww - hPTP
1z12 - bPTP + VO4
1z13 - bPTP + MoO4
3rof – PTP-A + peptide – Staphylococcus aureus
1u2p – MtPTP – Mycobacterium tuberculosis
1u2q – MtPTP + glycerol
2oz5 – MtPTP + inhibitor
2fek – PTP – Escherichia coli

Class III – CDC25

1c25 – hCDC25A catalytic domain (mutant)
1qb0, 1cwr, 1ym9, 1ymd, 1ymk, 1yml, 1ys0, 2uzq - hCDC25B catalytic domain
2a2k, 2ifd, 2ifv - hCDC25B catalytic domain (mutant)
1cwr, 1cws - hCDC25B catalytic domain + WO4
1cwt - hCDC25B catalytic domain + Methyl-Hg
3op3 – hCDC25C residues 270-462

T-cell PTP

1l8k – hTC-PTP