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1dz5

From Proteopedia

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[[Image:1dz5.png|left|200px]]
 
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{{STRUCTURE_1dz5| PDB=1dz5 | SCENE= }}
{{STRUCTURE_1dz5| PDB=1dz5 | SCENE= }}
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===The NMR structure of the 38KDa U1A protein-PIE RNA complex reveals the basis of cooperativity in regulation of polyadenylation by human U1A protein===
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{{ABSTRACT_PUBMED_10742179}}
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===THE NMR STRUCTURE OF THE 38KDA U1A PROTEIN-PIE RNA COMPLEX REVEALS THE BASIS OF COOPERATIVITY IN REGULATION OF POLYADENYLATION BY HUMAN U1A PROTEIN===
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==Function==
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[[http://www.uniprot.org/uniprot/SNRPA_HUMAN SNRPA_HUMAN]] Binds stem loop II of U1 snRNA. It is the first snRNP to interact with pre-mRNA. This interaction is required for the subsequent binding of U2 snRNP and the U4/U6/U5 tri-snRNP. In a snRNP-free form (SF-A) may be involved in coupled pre-mRNA splicing and polyadenylation process. Binds preferentially to the 5'-UGCAC-3' motif in vitro.<ref>PMID:9848648</ref>
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{{ABSTRACT_PUBMED_10742179}}
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==About this Structure==
==About this Structure==
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==Reference==
==Reference==
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<ref group="xtra">PMID:010742179</ref><references group="xtra"/>
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<ref group="xtra">PMID:010742179</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Gunderson, S I.]]
[[Category: Gunderson, S I.]]
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[[Category: Protein protein interaction]]
[[Category: Protein protein interaction]]
[[Category: Ribonucleoprotein-rna complex]]
[[Category: Ribonucleoprotein-rna complex]]
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[[Category: Ribonucleoprotein/rna]]
 
[[Category: Rna protein interaction]]
[[Category: Rna protein interaction]]
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[[Category: U1a protein]]
 

Revision as of 06:32, 16 May 2013

Template:STRUCTURE 1dz5

Contents

The NMR structure of the 38KDa U1A protein-PIE RNA complex reveals the basis of cooperativity in regulation of polyadenylation by human U1A protein

Template:ABSTRACT PUBMED 10742179

Function

[SNRPA_HUMAN] Binds stem loop II of U1 snRNA. It is the first snRNP to interact with pre-mRNA. This interaction is required for the subsequent binding of U2 snRNP and the U4/U6/U5 tri-snRNP. In a snRNP-free form (SF-A) may be involved in coupled pre-mRNA splicing and polyadenylation process. Binds preferentially to the 5'-UGCAC-3' motif in vitro.[1]

About this Structure

1dz5 is a 4 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

  • Varani L, Gunderson SI, Mattaj IW, Kay LE, Neuhaus D, Varani G. The NMR structure of the 38 kDa U1A protein - PIE RNA complex reveals the basis of cooperativity in regulation of polyadenylation by human U1A protein. Nat Struct Biol. 2000 Apr;7(4):329-35. PMID:10742179 doi:http://dx.doi.org/10.1038/74101
  1. ↑ Lutz CS, Cooke C, O'Connor JP, Kobayashi R, Alwine JC. The snRNP-free U1A (SF-A) complex(es): identification of the largest subunit as PSF, the polypyrimidine-tract binding protein-associated splicing factor. RNA. 1998 Dec;4(12):1493-9. PMID:9848648

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