2gku
From Proteopedia
(New page: 200px<br /><applet load="2gku" size="350" color="white" frame="true" align="right" spinBox="true" caption="2gku" /> '''Monomeric human telomere DNA tetraplex with ...) |
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==Overview== | ==Overview== | ||
| - | We present the intramolecular G-quadruplex structure of human telomeric | + | We present the intramolecular G-quadruplex structure of human telomeric DNA in physiologically relevant K(+) solution. This G-quadruplex, whose (3 + 1) topology differs from folds reported previously in Na(+) solution and in a K(+)-containing crystal, involves the following: one anti.syn.syn.syn and two syn.anti.anti.anti G-tetrads; one double-chain reversal and two edgewise loops; three G-tracts oriented in one direction and the fourth in the opposite direction. The topological characteristics of this (3 + 1) G-quadruplex scaffold should provide a unique platform for structure-based anticancer drug design targeted to human telomeric DNA. |
==About this Structure== | ==About this Structure== | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
| - | [[Category: Kuryavyi, V | + | [[Category: Kuryavyi, V V.]] |
[[Category: Lacroix, L.]] | [[Category: Lacroix, L.]] | ||
| - | [[Category: Luu, K | + | [[Category: Luu, K N.]] |
| - | [[Category: Patel, D | + | [[Category: Patel, D J.]] |
| - | [[Category: Phan, A | + | [[Category: Phan, A T.]] |
[[Category: 12 structures]] | [[Category: 12 structures]] | ||
[[Category: double-chain reversal loops; nmr]] | [[Category: double-chain reversal loops; nmr]] | ||
[[Category: g-tetrad; 3+1 strand folding;edgewise]] | [[Category: g-tetrad; 3+1 strand folding;edgewise]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:32:41 2008'' |
Revision as of 15:32, 21 February 2008
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Monomeric human telomere DNA tetraplex with 3+1 strand fold topology, two edgewise loops and double-chain reversal loop, NMR, 12 structures
Overview
We present the intramolecular G-quadruplex structure of human telomeric DNA in physiologically relevant K(+) solution. This G-quadruplex, whose (3 + 1) topology differs from folds reported previously in Na(+) solution and in a K(+)-containing crystal, involves the following: one anti.syn.syn.syn and two syn.anti.anti.anti G-tetrads; one double-chain reversal and two edgewise loops; three G-tracts oriented in one direction and the fourth in the opposite direction. The topological characteristics of this (3 + 1) G-quadruplex scaffold should provide a unique platform for structure-based anticancer drug design targeted to human telomeric DNA.
About this Structure
2GKU is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Structure of the human telomere in K+ solution: an intramolecular (3 + 1) G-quadruplex scaffold., Luu KN, Phan AT, Kuryavyi V, Lacroix L, Patel DJ, J Am Chem Soc. 2006 Aug 2;128(30):9963-70. PMID:16866556
Page seeded by OCA on Thu Feb 21 17:32:41 2008
