3znn

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'''Unreleased structure'''
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{{STRUCTURE_3znn| PDB=3znn | SCENE= }}
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===IN VITRO AND IN VIVO INHIBITION OF HUMAN D-AMINO ACID OXIDASE: REGULATION OF D-SERINE CONCENTRATION IN THE BRAIN===
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{{ABSTRACT_PUBMED_23631755}}
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The entry 3znn is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/OXDA_HUMAN OXDA_HUMAN]] Regulates the level of the neuromodulator D-serine in the brain. Has high activity towards D-DOPA and contributes to dopamine synthesis. Could act as a detoxifying agent which removes D-amino acids accumulated during aging. Acts on a variety of D-amino acids with a preference for those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups. Does not act on acidic amino acids.<ref>PMID:17303072</ref>
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Authors: Hopkins, S.C., Heffernan, M.L., Saraswat, L.D., Bowen, C.A., Melnick, L., Hardy, L.W., Orsini, M.A., Allen, M.S., Koch, P., Spear, K.L., Foglesong, R.J., Soukri, M., Chytil, M., Fang, K., Jones, S.W., Varney, M.A., Panatier, A., Oliet, S.H.R., Pollegioni, L., Piubelli, L., Molla, G., Nardini, M., Large, T.H.
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==About this Structure==
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[[3znn]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZNN OCA].
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Description: IN VITRO AND IN VIVO INHIBITION OF HUMAN D-AMINO ACID OXIDASE: REGULATION OF D-SERINE CONCENTRATION IN THE BRAIN
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==Reference==
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<references group="xtra"/><references/>
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[[Category: D-amino-acid oxidase]]
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[[Category: Homo sapiens]]
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[[Category: Allen, M S.]]
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[[Category: Bowen, C A.]]
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[[Category: Chytil, M.]]
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[[Category: Fang, Q K.]]
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[[Category: Foglesong, R J.]]
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[[Category: Hardy, L W.]]
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[[Category: Heffernan, M L.R.]]
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[[Category: Hopkins, S C.]]
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[[Category: Jones, S W.]]
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[[Category: Koch, P.]]
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[[Category: Large, T H.]]
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[[Category: Melnick, L.]]
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[[Category: Molla, G.]]
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[[Category: Nardini, M.]]
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[[Category: Oliet, S H.R.]]
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[[Category: Orsini, M A.]]
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[[Category: Panatier, A.]]
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[[Category: Piubelli, L.]]
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[[Category: Pollegioni, L.]]
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[[Category: Saraswat, L D.]]
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[[Category: Soukri, M.]]
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[[Category: Spear, K L.]]
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[[Category: Varney, M A.]]
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[[Category: Flavooxidase]]
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[[Category: Neurotransmission]]
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[[Category: Oxidoreductase]]

Revision as of 07:19, 16 May 2013

Template:STRUCTURE 3znn

Contents

IN VITRO AND IN VIVO INHIBITION OF HUMAN D-AMINO ACID OXIDASE: REGULATION OF D-SERINE CONCENTRATION IN THE BRAIN

Template:ABSTRACT PUBMED 23631755

Function

[OXDA_HUMAN] Regulates the level of the neuromodulator D-serine in the brain. Has high activity towards D-DOPA and contributes to dopamine synthesis. Could act as a detoxifying agent which removes D-amino acids accumulated during aging. Acts on a variety of D-amino acids with a preference for those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups. Does not act on acidic amino acids.[1]

About this Structure

3znn is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  1. ↑ Kawazoe T, Tsuge H, Imagawa T, Aki K, Kuramitsu S, Fukui K. Structural basis of D-DOPA oxidation by D-amino acid oxidase: alternative pathway for dopamine biosynthesis. Biochem Biophys Res Commun. 2007 Apr 6;355(2):385-91. Epub 2007 Feb 8. PMID:17303072 doi:10.1016/j.bbrc.2007.01.181

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OCA

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