4bkw

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m (Protected "4bkw" [edit=sysop:move=sysop])
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'''Unreleased structure'''
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{{STRUCTURE_4bkw| PDB=4bkw | SCENE= }}
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===Crystal structure of the C-terminal region of human ZFYVE9===
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The entry 4bkw is ON HOLD
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==Function==
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[[http://www.uniprot.org/uniprot/ZFYV9_HUMAN ZFYV9_HUMAN]] Early endosomal protein that functions to recruit SMAD2/SMAD3 to intracellular membranes and to the TGF-beta receptor. Plays a significant role in TGF-mediated signaling by regulating the subcellular location of SMAD2 and SMAD3 and modulating the transcriptional activity of the SMAD3/SMAD4 complex. Possibly associated with TGF-beta receptor internalization.<ref>PMID:9865696</ref> <ref>PMID:15356634</ref>
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Authors: Williams, E., Krojer, T., Vollmar, M., Shrestha, L., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Bullock, A.
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==About this Structure==
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[[4bkw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BKW OCA].
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Description: Crystal structure of the C-terminal region of human ZFYVE9
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Homo sapiens]]
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[[Category: Arrowsmith, C H.]]
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[[Category: Bountra, C.]]
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[[Category: Bullock, A.]]
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[[Category: Delft, F von.]]
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[[Category: Edwards, A M.]]
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[[Category: Krojer, T.]]
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[[Category: Shrestha, L.]]
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[[Category: Vollmar, M.]]
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[[Category: Williams, E.]]
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[[Category: Protein interaction domain]]
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[[Category: Receptor]]
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[[Category: Sgc]]
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[[Category: Tgf-beta and egfr signalling]]

Revision as of 07:28, 16 May 2013

Template:STRUCTURE 4bkw

Contents

Crystal structure of the C-terminal region of human ZFYVE9

Function

[ZFYV9_HUMAN] Early endosomal protein that functions to recruit SMAD2/SMAD3 to intracellular membranes and to the TGF-beta receptor. Plays a significant role in TGF-mediated signaling by regulating the subcellular location of SMAD2 and SMAD3 and modulating the transcriptional activity of the SMAD3/SMAD4 complex. Possibly associated with TGF-beta receptor internalization.[1] [2]

About this Structure

4bkw is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  1. ↑ Tsukazaki T, Chiang TA, Davison AF, Attisano L, Wrana JL. SARA, a FYVE domain protein that recruits Smad2 to the TGFbeta receptor. Cell. 1998 Dec 11;95(6):779-91. PMID:9865696
  2. ↑ Lin HK, Bergmann S, Pandolfi PP. Cytoplasmic PML function in TGF-beta signalling. Nature. 2004 Sep 9;431(7005):205-11. PMID:15356634 doi:10.1038/nature02783

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