3r3q

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[[Image:3r3q.png|left|200px]]
 
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{{STRUCTURE_3r3q| PDB=3r3q | SCENE= }}
{{STRUCTURE_3r3q| PDB=3r3q | SCENE= }}
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===Crystal structure of the yeast Vps23 UEV domain===
===Crystal structure of the yeast Vps23 UEV domain===
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{{ABSTRACT_PUBMED_21505419}}
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==Function==
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[[http://www.uniprot.org/uniprot/STP22_YEAST STP22_YEAST]] Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association to the ESCRT-0 complex. Required for vacuolar targeting of temperature-sensitive plasma membrane proteins STE2 and CAN1.<ref>PMID:10207082</ref> <ref>PMID:11208108</ref> <ref>PMID:11511343</ref>
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{{ABSTRACT_PUBMED_21505419}}
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==About this Structure==
==About this Structure==
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==Reference==
==Reference==
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<ref group="xtra">PMID:021505419</ref><references group="xtra"/>
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<ref group="xtra">PMID:021505419</ref><references group="xtra"/><references/>
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Hurley, J H.]]
[[Category: Hurley, J H.]]

Revision as of 07:44, 16 May 2013

Template:STRUCTURE 3r3q

Contents

Crystal structure of the yeast Vps23 UEV domain

Template:ABSTRACT PUBMED 21505419

Function

[STP22_YEAST] Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association to the ESCRT-0 complex. Required for vacuolar targeting of temperature-sensitive plasma membrane proteins STE2 and CAN1.[1] [2] [3]

About this Structure

3r3q is a 1 chain structure with sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

  • Ren X, Hurley JH. Structural basis for endosomal recruitment of ESCRT-I by ESCRT-0 in yeast. EMBO J. 2011 Apr 19. PMID:21505419 doi:10.1038/emboj.2011.122
  1. ↑ Li Y, Kane T, Tipper C, Spatrick P, Jenness DD. Yeast mutants affecting possible quality control of plasma membrane proteins. Mol Cell Biol. 1999 May;19(5):3588-99. PMID:10207082
  2. ↑ Babst M, Odorizzi G, Estepa EJ, Emr SD. Mammalian tumor susceptibility gene 101 (TSG101) and the yeast homologue, Vps23p, both function in late endosomal trafficking. Traffic. 2000 Mar;1(3):248-58. PMID:11208108
  3. ↑ Katzmann DJ, Babst M, Emr SD. Ubiquitin-dependent sorting into the multivesicular body pathway requires the function of a conserved endosomal protein sorting complex, ESCRT-I. Cell. 2001 Jul 27;106(2):145-55. PMID:11511343

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