3so5

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'''Unreleased structure'''
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{{STRUCTURE_3so5| PDB=3so5 | SCENE= }}
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===Crystal structure of an Immunoglobulin I-set domain of Lrig3 protein (Lrig3) from MUS MUSCULUS at 1.70 A resolution===
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The entry 3so5 is ON HOLD
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==Function==
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[[http://www.uniprot.org/uniprot/LRIG3_MOUSE LRIG3_MOUSE]] Plays a role in craniofacial and inner ear morphogenesis during embryonic development. Acts within the otic vesicle epithelium to control formation of the lateral semicircular canal in the inner ear, possibly by restricting the expression of NTN1.<ref>PMID:19004851</ref> <ref>PMID:20126551</ref>
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Authors: Joint Center for Structural Genomics (JCSG), Partnership for Stem Cell Biology
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==About this Structure==
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[[3so5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SO5 OCA].
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Description: Crystal structure of an Immunoglobulin I-set domain of Lrig3 protein (Lrig3) from MUS MUSCULUS at 1.70 A resolution
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Mus musculus]]
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[[Category: Biology, Partnership for Stem Cell.]]
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[[Category: JCSG, Joint Center for Structural Genomics.]]
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[[Category: Immunoglobulin]]
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[[Category: Jcsg]]
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[[Category: Joint center for structural genomic]]
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[[Category: Partnership for stem cell biology]]
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[[Category: Protein structure initiative]]
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[[Category: Psi-biology]]
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[[Category: Signaling protein]]
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[[Category: Structural genomic]]

Revision as of 07:48, 16 May 2013

Template:STRUCTURE 3so5

Contents

Crystal structure of an Immunoglobulin I-set domain of Lrig3 protein (Lrig3) from MUS MUSCULUS at 1.70 A resolution

Function

[LRIG3_MOUSE] Plays a role in craniofacial and inner ear morphogenesis during embryonic development. Acts within the otic vesicle epithelium to control formation of the lateral semicircular canal in the inner ear, possibly by restricting the expression of NTN1.[1] [2]

About this Structure

3so5 is a 2 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

  1. ↑ Abraira VE, Del Rio T, Tucker AF, Slonimsky J, Keirnes HL, Goodrich LV. Cross-repressive interactions between Lrig3 and netrin 1 shape the architecture of the inner ear. Development. 2008 Dec;135(24):4091-9. doi: 10.1242/dev.029330. Epub 2008 Nov 12. PMID:19004851 doi:10.1242/dev.029330
  2. ↑ Abraira VE, Satoh T, Fekete DM, Goodrich LV. Vertebrate Lrig3-ErbB interactions occur in vitro but are unlikely to play a role in Lrig3-dependent inner ear morphogenesis. PLoS One. 2010 Feb 1;5(2):e8981. doi: 10.1371/journal.pone.0008981. PMID:20126551 doi:10.1371/journal.pone.0008981

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