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3qzv
From Proteopedia
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{{STRUCTURE_3qzv| PDB=3qzv | SCENE= }} | {{STRUCTURE_3qzv| PDB=3qzv | SCENE= }} | ||
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===Crystal Structure of BPTF PHD-linker-bromo in complex with histone H4K12ac peptide=== | ===Crystal Structure of BPTF PHD-linker-bromo in complex with histone H4K12ac peptide=== | ||
| + | {{ABSTRACT_PUBMED_21596426}} | ||
| - | + | ==Function== | |
| - | + | [[http://www.uniprot.org/uniprot/BPTF_HUMAN BPTF_HUMAN]] Histone-binding component of NURF (nucleosome-remodeling factor), a complex which catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin. Specifically recognizes H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of virtually all active genes. May also regulate transcription through direct binding to DNA or transcription factors. | |
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==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID:021596426</ref><references group="xtra"/> | + | <ref group="xtra">PMID:021596426</ref><references group="xtra"/><references/> |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Li, H.]] | [[Category: Li, H.]] | ||
Revision as of 07:50, 16 May 2013
Contents |
Crystal Structure of BPTF PHD-linker-bromo in complex with histone H4K12ac peptide
Template:ABSTRACT PUBMED 21596426
Function
[BPTF_HUMAN] Histone-binding component of NURF (nucleosome-remodeling factor), a complex which catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin. Specifically recognizes H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of virtually all active genes. May also regulate transcription through direct binding to DNA or transcription factors.
About this Structure
3qzv is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Ruthenburg AJ, Li H, Milne TA, Dewell S, McGinty RK, Yuen M, Ueberheide B, Dou Y, Muir TW, Patel DJ, Allis CD. Recognition of a Mononucleosomal Histone Modification Pattern by BPTF via Multivalent Interactions. Cell. 2011 May 27;145(5):692-706. Epub 2011 May 19. PMID:21596426 doi:10.1016/j.cell.2011.03.053
