3rq3
From Proteopedia
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{{STRUCTURE_3rq3| PDB=3rq3 | SCENE= }} | {{STRUCTURE_3rq3| PDB=3rq3 | SCENE= }} | ||
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===Structure of T-cell immunoreceptor with immunoglobulin and ITIM domains (TIGIT) in hexagonal crystal form=== | ===Structure of T-cell immunoreceptor with immunoglobulin and ITIM domains (TIGIT) in hexagonal crystal form=== | ||
| + | ==Function== | ||
| + | [[http://www.uniprot.org/uniprot/TIGIT_HUMAN TIGIT_HUMAN]] Binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells. | ||
==About this Structure== | ==About this Structure== | ||
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[[Category: Rubinstein, R.]] | [[Category: Rubinstein, R.]] | ||
[[Category: Samanta, D.]] | [[Category: Samanta, D.]] | ||
| + | [[Category: Adhesion]] | ||
| + | [[Category: Atoms-to-animals: the immune function network]] | ||
| + | [[Category: Ifn]] | ||
| + | [[Category: Ig-domain]] | ||
| + | [[Category: Immune receptor]] | ||
| + | [[Category: Immune system]] | ||
| + | [[Category: New york structural genomics research consortium]] | ||
| + | [[Category: Nysgrc]] | ||
| + | [[Category: Psi-biology]] | ||
| + | [[Category: Structural genomic]] | ||
| + | [[Category: Tigit]] | ||
Revision as of 08:00, 16 May 2013
Structure of T-cell immunoreceptor with immunoglobulin and ITIM domains (TIGIT) in hexagonal crystal form
Function
[TIGIT_HUMAN] Binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells.
About this Structure
3rq3 is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Categories: Homo sapiens | Almo, S C. | Guo, H. | IFN, Atoms-to-Animals:.The Immune Function Network. | NYSGRC, New York Structural Genomics Research Consortium. | Nathenson, S G. | Ramagopal, U A. | Rubinstein, R. | Samanta, D. | Adhesion | Atoms-to-animals: the immune function network | Ifn | Ig-domain | Immune receptor | Immune system | New york structural genomics research consortium | Nysgrc | Psi-biology | Structural genomic | Tigit
