3s24

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[[Image:3s24.png|left|200px]]
 
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{{STRUCTURE_3s24| PDB=3s24 | SCENE= }}
{{STRUCTURE_3s24| PDB=3s24 | SCENE= }}
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===Crystal structure of human mRNA guanylyltransferase===
===Crystal structure of human mRNA guanylyltransferase===
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{{ABSTRACT_PUBMED_21636784}}
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==Function==
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[[http://www.uniprot.org/uniprot/MCE1_HUMAN MCE1_HUMAN]] Bifunctional mRNA-capping enzyme exhibiting RNA 5'-triphosphatase activity in the N-terminal part and mRNA guanylyltransferase activity in the C-terminal part. Catalyzes the first two steps of cap formation: by removing the gamma-phosphate from the 5'-triphosphate end of nascent mRNA to yield a diphosphate end, and by transferring the gmp moiety of GTP to the 5'-diphosphate terminus.
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{{ABSTRACT_PUBMED_21636784}}
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==About this Structure==
==About this Structure==
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==Reference==
==Reference==
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<ref group="xtra">PMID:021636784</ref><references group="xtra"/>
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<ref group="xtra">PMID:021636784</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Arnold, E.]]
[[Category: Arnold, E.]]

Revision as of 08:00, 16 May 2013

Template:STRUCTURE 3s24

Contents

Crystal structure of human mRNA guanylyltransferase

Template:ABSTRACT PUBMED 21636784

Function

[MCE1_HUMAN] Bifunctional mRNA-capping enzyme exhibiting RNA 5'-triphosphatase activity in the N-terminal part and mRNA guanylyltransferase activity in the C-terminal part. Catalyzes the first two steps of cap formation: by removing the gamma-phosphate from the 5'-triphosphate end of nascent mRNA to yield a diphosphate end, and by transferring the gmp moiety of GTP to the 5'-diphosphate terminus.

About this Structure

3s24 is a 7 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Chu C, Das K, Tyminski JR, Bauman JD, Guan R, Qiu W, Montelione GT, Arnold E, Shatkin AJ. Structure of the guanylyltransferase domain of human mRNA capping enzyme. Proc Natl Acad Sci U S A. 2011 Jun 2. PMID:21636784 doi:10.1073/pnas.1106610108

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OCA

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