3rom

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'''Unreleased structure'''
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{{STRUCTURE_3rom| PDB=3rom | SCENE= }}
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===Crystal structure of human CD38 in complex with compound CZ-48===
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{{ABSTRACT_PUBMED_22142305}}
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The entry 3rom is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/CD38_HUMAN CD38_HUMAN]] Synthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system.
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Authors: Zhang, H., Lee, H.C., Hao, Q.
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==About this Structure==
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[[3rom]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ROM OCA].
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Description: Crystal structure of human CD38 in complex with compound CZ-48
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==See Also==
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*[[Cluster of Differentiation 38|Cluster of Differentiation 38]]
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==Reference==
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<ref group="xtra">PMID:022142305</ref><references group="xtra"/><references/>
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[[Category: Homo sapiens]]
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[[Category: Hao, Q.]]
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[[Category: Lee, H C.]]
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[[Category: Zhang, H.]]
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[[Category: Adp-ribosyl cyclase]]
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[[Category: Calcium signaling]]
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[[Category: Cd38]]
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[[Category: Covalent intermediate]]
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[[Category: Cyclic adp-ribose]]
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[[Category: Cz-48]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Inhibitory compound]]
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[[Category: X-crystallography]]

Revision as of 08:06, 16 May 2013

Template:STRUCTURE 3rom

Contents

Crystal structure of human CD38 in complex with compound CZ-48

Template:ABSTRACT PUBMED 22142305

Function

[CD38_HUMAN] Synthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system.

About this Structure

3rom is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

Reference

  • Kwong AK, Chen Z, Zhang H, Leung FP, Lam CM, Ting KY, Zhang L, Hao Q, Zhang LH, Lee HC. Catalysis-Based Inhibitors of the Calcium Signaling Function of CD38. Biochemistry. 2011 Dec 14. PMID:22142305 doi:10.1021/bi201509f

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OCA

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