Pteridine reductase (PTR) catalyzes the reduction of 5,6,7,8-tetrahydrobiopterin (THBP) to biopterin. PTR is part of pterin and folate metabolism. NADP is the hydrogen acceptor in this reduction. PTR is essential for growth of trypanosomatid protozoans like Leishmania parasites, thus PTR inhibitors like methotrexate (MTX) or triaminoquinazoline (TAQ) are tested as potential drugs.
3D structures of pteridine reductase
Updated on 19-May-2013
2xox – LdPTR1 (mutant) – Leishmania donovani
2bfo – LmPTR1 + NADPH – Leishmania major
Pteridine reductase complex with inhibitor
1e7w – LmPTR1 + NADPH + MTX
1w0c – LmPTR1 + NADPH + TAQ
1p33 – PTR1 + NADPH + MTX – Leishmania tarentolae
1mxf – TcPTR2 + NADPH + MTX – Trypanosoma cruzi
2c7v – TbPTR1 + NADPH + MTX – Trypanosoma brucei
3bmn, 3bmo, 3bmq, 2wd7, 2wd8, 2vz0, 3jq6, 3jq7, 3jq8, 3jq9, 3jqa, 3jqb, 3jqc, 3jqf, 3jqd, 3jqe, 3jqg, 3gn1, 3gn2, 3mcv, 2x9g, 2x9v, 2x9n, 2yhi, 2yhu – TbPTR1 + NADPH + inhibitor
2bfa, 2bfm, 3h4v – LmPTR1 + NADPH + inhibitor
Pteridine reductase complex with ligand
2bfp – LmPTR1 + NADPH + THBP
2qhx – LmPTR1 + NADPH + ligand
1e92, 2bf7 – LmPTR1 + NADPH + DHBP
1mxh – TcPTR1 + NADPH + folate
3bmc – TbPTR1 + NADPH + folate
