2gtm
From Proteopedia
(New page: 200px<br /><applet load="2gtm" size="450" color="white" frame="true" align="right" spinBox="true" caption="2gtm, resolution 1.90Å" /> '''Mutated Mouse P38 MA...) |
|||
| Line 1: | Line 1: | ||
| - | [[Image:2gtm.gif|left|200px]]<br /><applet load="2gtm" size=" | + | [[Image:2gtm.gif|left|200px]]<br /><applet load="2gtm" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="2gtm, resolution 1.90Å" /> | caption="2gtm, resolution 1.90Å" /> | ||
'''Mutated Mouse P38 MAP Kinase Domain in complex with Inhibitor PG-892579'''<br /> | '''Mutated Mouse P38 MAP Kinase Domain in complex with Inhibitor PG-892579'''<br /> | ||
==Overview== | ==Overview== | ||
| - | A series of C-2, C-8, and N-9 trisubstituted purine based inhibitors of | + | A series of C-2, C-8, and N-9 trisubstituted purine based inhibitors of TNF-alpha production are described. The most potent analogs showed low nanomolar activity against LPS-induced TNF-alpha production in a THP-1 cell based assay. The SAR of the series was optimized with the aid of X-ray co-crystal structures of these inhibitors bound with mutated p38 (mp38). |
==About this Structure== | ==About this Structure== | ||
| - | 2GTM is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] with LID as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Mitogen-activated_protein_kinase Mitogen-activated protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.24 2.7.11.24] Full crystallographic information is available from [http:// | + | 2GTM is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] with <scene name='pdbligand=LID:'>LID</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Mitogen-activated_protein_kinase Mitogen-activated protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.24 2.7.11.24] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GTM OCA]. |
==Reference== | ==Reference== | ||
| Line 14: | Line 14: | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Evdokimov, A | + | [[Category: Evdokimov, A G.]] |
| - | [[Category: Mekel, M | + | [[Category: Mekel, M J.]] |
| - | [[Category: Pokross, M | + | [[Category: Pokross, M E.]] |
[[Category: Sabat, M.]] | [[Category: Sabat, M.]] | ||
| - | [[Category: Walter, R | + | [[Category: Walter, R L.]] |
[[Category: LID]] | [[Category: LID]] | ||
[[Category: map kinase p38]] | [[Category: map kinase p38]] | ||
[[Category: p38]] | [[Category: p38]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:35:15 2008'' |
Revision as of 15:35, 21 February 2008
|
Mutated Mouse P38 MAP Kinase Domain in complex with Inhibitor PG-892579
Overview
A series of C-2, C-8, and N-9 trisubstituted purine based inhibitors of TNF-alpha production are described. The most potent analogs showed low nanomolar activity against LPS-induced TNF-alpha production in a THP-1 cell based assay. The SAR of the series was optimized with the aid of X-ray co-crystal structures of these inhibitors bound with mutated p38 (mp38).
About this Structure
2GTM is a Single protein structure of sequence from Mus musculus with as ligand. Active as Mitogen-activated protein kinase, with EC number 2.7.11.24 Full crystallographic information is available from OCA.
Reference
The development of novel C-2, C-8, and N-9 trisubstituted purines as inhibitors of TNF-alpha production., Sabat M, Vanrens JC, Clark MP, Brugel TA, Maier J, Bookland RG, Laufersweiler MJ, Laughlin SK, Golebiowski A, De B, Hsieh LC, Walter RL, Mekel MJ, Janusz MJ, Bioorg Med Chem Lett. 2006 Aug 15;16(16):4360-5. Epub 2006 Jun 5. PMID:16750367
Page seeded by OCA on Thu Feb 21 17:35:15 2008
