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3ax1

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===Molecular insights into miRNA processing by Arabidopsis Serrate===
===Molecular insights into miRNA processing by Arabidopsis Serrate===
{{ABSTRACT_PUBMED_21685453}}
{{ABSTRACT_PUBMED_21685453}}
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==Function==
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[[http://www.uniprot.org/uniprot/SRRT_ARATH SRRT_ARATH]] Acts as a mediator between the cap-binding complex (CBC) and both the pre-mRNA splicing and primary microRNAs (miRNAs) processing machinery. Required for proper processing of primary miRNAs to miRNAs, thereby playing a role in RNA-mediated gene silencing (RNAi) by miRNAs. Does not participate in sense post-transcriptional gene silencing. Acts as a regulator of meristem activity and adaxial leaf fate via the miRNA gene-silencing pathway by regulating the expression of PHB and by limiting the competence of shoot tissue to respond to KNOX expression. Its function is however not limited to miRNA-mediated repression of leaf polarity genes, but rather acts as a general regulator of primary microRNAs processing. Also critical for the accumulation of the trans-acting small interfering RNA (ta-siRNA). Required for pre-mRNA splicing.<ref>PMID:16222298</ref> <ref>PMID:16977334</ref> <ref>PMID:16889646</ref> <ref>PMID:18632569</ref> <ref>PMID:18550839</ref>
==About this Structure==
==About this Structure==

Revision as of 08:25, 19 June 2013

Template:STRUCTURE 3ax1

Contents

Molecular insights into miRNA processing by Arabidopsis Serrate

Template:ABSTRACT PUBMED 21685453

Function

[SRRT_ARATH] Acts as a mediator between the cap-binding complex (CBC) and both the pre-mRNA splicing and primary microRNAs (miRNAs) processing machinery. Required for proper processing of primary miRNAs to miRNAs, thereby playing a role in RNA-mediated gene silencing (RNAi) by miRNAs. Does not participate in sense post-transcriptional gene silencing. Acts as a regulator of meristem activity and adaxial leaf fate via the miRNA gene-silencing pathway by regulating the expression of PHB and by limiting the competence of shoot tissue to respond to KNOX expression. Its function is however not limited to miRNA-mediated repression of leaf polarity genes, but rather acts as a general regulator of primary microRNAs processing. Also critical for the accumulation of the trans-acting small interfering RNA (ta-siRNA). Required for pre-mRNA splicing.[1] [2] [3] [4] [5]

About this Structure

3ax1 is a 1 chain structure with sequence from Arabidopsis thaliana. Full crystallographic information is available from OCA.

Reference

  • Machida S, Chen HY, Adam Yuan Y. Molecular insights into miRNA processing by Arabidopsis thaliana SERRATE. Nucleic Acids Res. 2011 Jun 17. PMID:21685453 doi:10.1093/nar/gkr428
  1. ↑ Grigg SP, Canales C, Hay A, Tsiantis M. SERRATE coordinates shoot meristem function and leaf axial patterning in Arabidopsis. Nature. 2005 Oct 13;437(7061):1022-6. PMID:16222298 doi:10.1038/nature04052
  2. ↑ Lobbes D, Rallapalli G, Schmidt DD, Martin C, Clarke J. SERRATE: a new player on the plant microRNA scene. EMBO Rep. 2006 Oct;7(10):1052-8. Epub 2006 Sep 15. PMID:16977334 doi:10.1038/sj.embor.7400806
  3. ↑ Yang L, Liu Z, Lu F, Dong A, Huang H. SERRATE is a novel nuclear regulator in primary microRNA processing in Arabidopsis. Plant J. 2006 Sep;47(6):841-50. Epub 2006 Aug 2. PMID:16889646 doi:10.1111/j.1365-313X.2006.02835.x
  4. ↑ Dong Z, Han MH, Fedoroff N. The RNA-binding proteins HYL1 and SE promote accurate in vitro processing of pri-miRNA by DCL1. Proc Natl Acad Sci U S A. 2008 Jul 22;105(29):9970-5. doi:, 10.1073/pnas.0803356105. Epub 2008 Jul 16. PMID:18632569 doi:10.1073/pnas.0803356105
  5. ↑ Laubinger S, Sachsenberg T, Zeller G, Busch W, Lohmann JU, Ratsch G, Weigel D. Dual roles of the nuclear cap-binding complex and SERRATE in pre-mRNA splicing and microRNA processing in Arabidopsis thaliana. Proc Natl Acad Sci U S A. 2008 Jun 24;105(25):8795-800. doi:, 10.1073/pnas.0802493105. Epub 2008 Jun 12. PMID:18550839 doi:10.1073/pnas.0802493105

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